Evaluation of multidrug resistance-1 gene C > T polymorphism frequency in patients with asthma

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dc.authorid0000-0002-6272-4173en_US
dc.authorid0000-0001-9988-8983
dc.contributor.authorToru, Ümran
dc.contributor.authorAyada, Ceylan
dc.contributor.authorGenç, Osman
dc.contributor.authorYaşar, Zehra
dc.contributor.authorŞahin, Server
dc.date.accessioned2021-06-23T19:42:28Z
dc.date.available2021-06-23T19:42:28Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVES: Asthma is a chronic inflammatory lung disease characterized by bronchial hyperresponsiveness and airflow obstruction. Genetic and oxidative stress factors, in addition to pulmonary and systemic inflammatory processes, play a pivotal role in the pathogenesis of asthma. The products of the multidrug resistance-1 gene protect lung tissue from oxidative stress. Here, we aimed to evaluate the association between the multidrug resistance-1 gene C>T polymorphism and asthma with regard to oxidative stress-related parameters of asthmatic patients. METHODS: Forty-five patients with asthma and 27 healthy age-matched controls were included in this study. Blood samples were collected in tubes with ethylenediaminetetraacetic acid. DNA was extracted from the blood samples. The multidrug resistance-1 gene polymorphism was detected by polymerase chain reaction and a subsequent enzyme digestion technique. The serum levels of total oxidant status and total antioxidant status were determined by the colorimetric measurement method. RESULTS: The heterozygous polymorphic genotype was the most frequent in both groups. A significant difference in the multidrug resistance-1 genotype frequencies between groups indicated an association of asthma with the TT genotype. A significant difference between groups was found for wild type homozygous participants and carriers of polymorphic allele participants. The frequency of the T allele was significantly higher in asthmatic patients. The increase in the oxidative stress index parameter was significant in the asthma group compared with the control group. CONCLUSIONS: The multidrug resistance-1 gene C/T polymorphism may be an underlying genetic risk factor for the development of asthma via oxidant-antioxidant imbalance, leading to increased oxidative stress.en_US
dc.identifier.doi10.6061/clinics/2015(10)02
dc.identifier.endpage674en_US
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.issue10en_US
dc.identifier.pmid26598078en_US
dc.identifier.scopus2-s2.0-84945380448en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage670en_US
dc.identifier.urihttps://doi.org/10.6061/clinics/2015(10)02
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8503
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1807593222013242?via%3Dihub
dc.identifier.volume70en_US
dc.identifier.wosWOS:000364422500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYaşar, Zehra
dc.language.isoenen_US
dc.publisherHospital Clinicas, Univ Sao Pauloen_US
dc.relation.ispartofClinicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultidrug Resistance-1 Geneen_US
dc.subjectPolymorphismen_US
dc.subjectP-Glycoproteinen_US
dc.subjectAsthmaen_US
dc.subjectInflammationen_US
dc.subjectOxidative Stressen_US
dc.titleEvaluation of multidrug resistance-1 gene C > T polymorphism frequency in patients with asthmaen_US
dc.typeArticleen_US

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