A comprehensive study of oxidative stress in patients with somatic symptom disorder

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dc.authorid0000-0002-2996-3236en_US
dc.authorid0000-0002-5806-562X
dc.authorid0000-0003-1586-9334
dc.authorid0000-0003-1320-0119
dc.contributor.authorŞahin, Esra Kabadayı
dc.contributor.authorÇayköylü, Ali
dc.contributor.authorŞenat, Almila
dc.contributor.authorErel, Özcan
dc.date.accessioned2021-06-23T19:51:56Z
dc.date.available2021-06-23T19:51:56Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5. Methods The study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups. Results TOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p < 0.001). There was no significant difference in PON, ARE, and TAS parameters between the two groups (p > 0.05). Conclusion This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder.en_US
dc.identifier.doi10.1017/neu.2018.33
dc.identifier.endpage105en_US
dc.identifier.issn1601-5215
dc.identifier.issue2en_US
dc.identifier.pmid30558690en_US
dc.identifier.scopus2-s2.0-85063897462en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2018.33
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10071
dc.identifier.volume31en_US
dc.identifier.wosWOS:000463078900005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞahin, Esra Kabadayı
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectPONen_US
dc.subjectSomatic Symptom Disorderen_US
dc.subjectThiol-disulphide Homeostasisen_US
dc.titleA comprehensive study of oxidative stress in patients with somatic symptom disorderen_US
dc.typeArticleen_US

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