Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

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dc.authorid0000-0002-5240-4504
dc.contributor.authorÖzdem, Muhsin
dc.contributor.authorKırzıoğlu, Fatma Y.
dc.contributor.authorYılmaz, Hacı R.
dc.contributor.authorVural, Hüseyin
dc.contributor.authorFentoğlu, Özlem
dc.date.accessioned2021-06-23T19:48:58Z
dc.date.available2021-06-23T19:48:58Z
dc.date.issued2017
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties. Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.en_US
dc.identifier.doi10.2334/josnusd.16-0034
dc.identifier.endpage29en_US
dc.identifier.issn1343-4934
dc.identifier.issn1880-4926
dc.identifier.issue1en_US
dc.identifier.pmid28367898en_US
dc.identifier.scopus2-s2.0-85016616898en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.2334/josnusd.16-0034
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9285
dc.identifier.volume59en_US
dc.identifier.wosWOS:000399263300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzdem, Muhsin
dc.language.isoenen_US
dc.publisherNihon Univ, School Dentistryen_US
dc.relation.ispartofJournal Of Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidantsen_US
dc.subjectExperimental Periodontitisen_US
dc.titleAntioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in ratsen_US
dc.typeArticleen_US

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