The effect of sildenafil on selenite-induced cataract in rats

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dc.authorid0000-0001-9945-793Xen_US
dc.authorid0000-0002-4336-2517en_US
dc.contributor.authorAtalay, Hatice Tuba
dc.contributor.authorÜçgül, Ahmet Yücel
dc.contributor.authorTürkçü, Ümmühani Özel
dc.contributor.authorÖzmen, Mehmet Cüneyt
dc.contributor.authorYılmaz, Samet
dc.contributor.authorBilgihan, Ayşe
dc.date.accessioned2021-06-23T19:54:32Z
dc.date.available2021-06-23T19:54:32Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To investigate the effect of sildenafil on an experimental sodium selenite-induced cataract model in rats. Materials and Methods: Twenty-six young Wistar rats were separated into four groups. On postpartum day 10, six rats received only selenite (group 1, selenite-induced cataract), seven rats received selenite and high dose oral sildenafil (group 2, high-dose sildenafil-treated), seven rats received selenite and low dose oral sildenafil (group 3, low-dose sildenafil-treated), and six rats received only saline (group 4, controls). On postpartum day 30, cataract formation was graded and recorded using an operating microscope. The rats were sacrificed, lens tissues were isolated, and serum samples were collected. Nitrite oxide metabolites (NOx), advanced oxidative protein products (AOPP), and total sulfhydryl (TSH) levels were assessed in both serum and lenticular samples. Results: The rats treated with low-dose sildenafil showed lower levels of AOPP and NOx, and the higher levels of TSH than the rats in other experimental groups. Otherwise, the rats treated with high-dose sildenafil, similar to the selenite-induced cataract group, showed higher levels of AOPP and serum NOx than rats in the low-dose sildenafil-treated group. The rats treated with low-dose sildenafil also showed less cataract development than rats in the other experimental groups. Conclusion: Low doses (0.7 mg/kg) of oral sildenafil might show a protective effect on cataract development by lowering oxidative stress.en_US
dc.identifier.doi10.1080/02713683.2020.1726405
dc.identifier.endpage1088en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue9en_US
dc.identifier.pmid32023416en_US
dc.identifier.scopus2-s2.0-85079375788en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1082en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2020.1726405
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10572
dc.identifier.volume45en_US
dc.identifier.wosWOS:000525895600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜçgül, Ahmet Yücel
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAOPPen_US
dc.subjectCataract Modelen_US
dc.subjectNOxen_US
dc.subjectSeleniteen_US
dc.subjectSildenafilen_US
dc.subjectTotal Sulfhydrylen_US
dc.titleThe effect of sildenafil on selenite-induced cataract in ratsen_US
dc.typeArticleen_US

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