HbA1c/C-peptide ratio is associated with angiographic thrombus burden and short-term mortality in patients presenting with ST-elevation myocardial infarction

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dc.authorid0000-0001-8923-8709en_US
dc.authorid0000-0002-4297-1820en_US
dc.authorid0000-0002-3183-5815en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0002-7234-6321en_US
dc.authorid0000-0002-9008-6631en_US
dc.contributor.authorToprak, Kenan
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorMemioğlu, Tolga
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorOmar, Bahadır
dc.contributor.authorTaşcanov, Mustafa Begenç
dc.date.accessioned2024-05-29T07:37:40Z
dc.date.available2024-05-29T07:37:40Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectivesAngiographic high thrombus burden (HTB) is associated with increased adverse cardiovascular events in patients with ST-elevation myocardial infarction (STEMI). HbA1c and C-peptide are two interrelated bioactive markers that affect many cardiovascular pathways. HbA1c exhibits prothrombogenic properties, while C-peptide, in contrast, exhibits antithrombogenic effects. In this study, we aimed to demonstrate the value of combining these two biomarkers in a single fraction in predicting HTB and short-term mortality in patients with STEMI.Methods1202 patients who underwent primary percutaneous coronary intervention (pPCI) for STEMI were retrospectively included in this study. The study population was divided into thrombus burden (TB) groups and compared in terms of basic clinical demographics, laboratory parameters and HbA1c/C-peptide ratios (HCR). In addition, short-term mortality of the study population was compared according to HCR and TB categories.ResultsHCR values were significantly higher in the HTB group than in the LTB group (3.5 & PLUSMN; 1.2 vs. 2.0 & PLUSMN; 1.1; P < 0.001; respectively). In the multivariable regression analysis, HCR was determined as an independent predictor of HTB both as a continuous variable [odds ratio (OR): 2.377; confidence interval (CI): 2.090-2.704; P < 0.001] and as a categorical variable (OR: 5.492; CI: 4.115-7.331; P < 0.001). In the receiver operating characteristic (ROC) analysis, HCR predicted HTB with 73% sensitivity and 72% specificity, and furthermore, HCR's predictive value for HTB was superior to HbA1c and C-peptide. The Kaplan-Meier cumulative survival curve showed that short-term mortality increased at HTB. In addition, HCR strongly predicted short-term mortality in Cox regression analysis.ConclusionsIn conclusion, HCR is closely associated with HTB and short-term mortality in STEMI patients.en_US
dc.identifier.citationToprak, K., Kaplangöray, M., Memioğlu, T., İnanir, M., Omar, B., Taşcanov, M. B., ... & Demirbağ, R. (2023). HbA1c/C-peptide ratio is associated with angiographic thrombus burden and short-term mortality in patients presenting with ST-elevation myocardial infarction. Blood Coagulation & Fibrinolysis, 34(6), 385-395.en_US
dc.identifier.doi10.1097/MBC.0000000000001240
dc.identifier.endpage395en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue6en_US
dc.identifier.pmid37577863en_US
dc.identifier.scopus2-s2.0-85168242687en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage385en_US
dc.identifier.urihttp://dx.doi.org/10.1097/MBC.0000000000001240
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12182
dc.identifier.volume34en_US
dc.identifier.wosWOS:001050273900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMemioğlu, Tolga
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Peptideen_US
dc.subjectHbA1cen_US
dc.subjectShort-Term Mortalityen_US
dc.subjectST-Elevation Myocardial Infarctionen_US
dc.subjectThrombus Burdenen_US
dc.subjectPathophysiologyen_US
dc.titleHbA1c/C-peptide ratio is associated with angiographic thrombus burden and short-term mortality in patients presenting with ST-elevation myocardial infarctionen_US
dc.typeArticleen_US

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