Effects of melatonin on Candida sepsis in an experimental rat model

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dc.authorid0000-0002-1964-424Xen_US
dc.authorid0000-0001-8224-8242
dc.authorid0000-0002-5676-6983
dc.authorid0000-0002-4330-2864
dc.authorid0000-0003-1937-9244
dc.contributor.authorYavuz, Tevfik
dc.contributor.authorKaya, Demet
dc.contributor.authorBehçet, Mustafa
dc.contributor.authorÖztürk, Elif
dc.contributor.authorYavuz, Özlem
dc.date.accessioned2021-06-23T19:20:36Z
dc.date.available2021-06-23T19:20:36Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAs an immunomodulator, melatonin reportedly exhibits protective effects in severe sepsis/shock induced by bacterial lipopolysaccharides in animal models. The present study was conducted to evaluate the possible protective effects of melatonin against experimental Cindida sepsis in rats. A total of 40 adult male Wistar rats were randomly assigned to 4 groups: control, melatonin-treated control, septic, and melatonin-treated septic. Melatonin (200 mu g/kg/d, intraperitoneally) injections were begun a week prior to sepsis induction and were continued daily for 3 wk until the end of the study. Cyclophosphamide was administered to animals in all groups as an immunosuppressive agent as a single dose 4 d prior to yeast inoculation. To cause sepsis, the Candida albicans (ATCC 10259) strain was administered intravenously. Amphotericin B was given as an antimycotic therapeutic agent as a single dose to septic rats. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1, and E-selectin were measured on the first and 15th days of sepsis. L-6, TNF-alpha, vascular cell adhesion molecule-1, and E-selectin levels of septic rats were higher than those of controls. Melatonin reduced IL-6 levels and shortened time to improvement in animals with Candida sepsis. Levels of TNF-alpha and adhesion molecules in melatonin-treated septic rats were decreased compared with those in septic rats, but this difference was not statistically significant. In light of the current results, investigators conclude that melatonin may have therapeutic benefits in Candida sepsis and in classic antimycotic treatment because of its immune regulatory effects.en_US
dc.identifier.doi10.1007/BF02849996
dc.identifier.endpage100en_US
dc.identifier.issn0741-238X
dc.identifier.issn1865-8652
dc.identifier.issue1en_US
dc.identifier.pmid17526465en_US
dc.identifier.scopus2-s2.0-34247871353en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1007/BF02849996
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6140
dc.identifier.volume24en_US
dc.identifier.wosWOS:000246229900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Tevfik
dc.institutionauthorKaya, Demet
dc.institutionauthorBehçet, Mustafa
dc.institutionauthorÖztürk, Elif
dc.institutionauthorYavuz, Özlem
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances In Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectCandidaen_US
dc.subjectSepsisen_US
dc.subjectCytokinesen_US
dc.subjectAdhesion moleculesen_US
dc.titleEffects of melatonin on Candida sepsis in an experimental rat modelen_US
dc.typeArticleen_US

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