Comparison of early versus late onset familial mediterranean fever

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dc.authorid0000-0001-7737-4180en_US
dc.authorid0000-0001-6902-624Xen_US
dc.authorid0000-0003-3628-8870en_US
dc.authorid0000-0002-0783-1072en_US
dc.authorid0000-0002-6150-3539en_US
dc.authorid0000-0002-4691-3417en_US
dc.authorid0000-0001-5184-4404en_US
dc.authorid0000-0002-1730-2991
dc.contributor.authorBilge, Nazife Şule Yaşar
dc.contributor.authorSarı, İsmail
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorŞenel, Soner
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorKılıç, Levent
dc.contributor.authorYılmaz Öner, Sibel
dc.contributor.authorBes, Cemal
dc.date.accessioned2021-06-23T19:49:50Z
dc.date.available2021-06-23T19:49:50Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAimFamilial Mediterranean fever (FMF) is the most common autoinflammatory disease. One of the common characteristics of this disease is its young age predominance. Nearly 90% of patients experience disease flares during early adult age periods. Currently there are limited data for the comparison of early versus late onset FMF and therefore the primary aim of this study was to investigate these two subsets with regard to their certain demographic, clinical and genetic differences. MethodsEarly (20years, Group 1) and late (>20years, Group 2) onset FMF patients were identified from the national FMF registry that involves 2246 patients from 15 adult rheumatology clinics located in different geographical areas of Turkey. ResultsOf the 2246 patients, 1633 (72.7%) were aged 20years old (Group 1) and the remaining 613 were older than 20years (Group 2). Delay in diagnosis was longer in Group 1 and fever, peritonitis, pleuritis, erysipelas-like erythema (ELE), arthritis, family history of FMF and amyloidosis were more common in Group 1. On the other hand, sex distribution, rates of amyloidosis, vasculitis and kidney failure were not different between the groups. Among patients with available genotypes, homozygous and heterozygous M694V mutations weresignificantly higher and heterozygous E148Q mutation was significantly lower in Group 1 compared to Group 2. ConclusionPatients with FMF whose symptoms start before 20years of age seem to have severe symptoms and M694V mutation may be responsible for the early expression of the disease.en_US
dc.identifier.doi10.1111/1756-185X.13259
dc.identifier.endpage884en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue4en_US
dc.identifier.pmid29314707en_US
dc.identifier.scopus2-s2.0-85052001412en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage880en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9632
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13259
dc.identifier.volume21en_US
dc.identifier.wosWOS:000429000500014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBes, Cemal
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAge At Onset Of Diseaseen_US
dc.subjectEarly Onseten_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectM694Ven_US
dc.titleComparison of early versus late onset familial mediterranean feveren_US
dc.typeArticleen_US

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