The therapeutic effects of cyclosporin-A on experimental spinal cord injury.

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dc.authorid0000-0002-3260-7419en_US
dc.authorid0000-0001-5050-7908
dc.authorid0000-0002-8317-7092
dc.contributor.authorGezici, Ali Rıza
dc.contributor.authorKılıç, Güven
dc.contributor.authorFırat, Tülin
dc.contributor.authorCancan, Seçkin Emre
dc.contributor.authorKükner, Aysel
dc.date.accessioned2021-06-23T19:49:11Z
dc.date.available2021-06-23T19:49:11Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: According to the experiments, neutrophils and microglial cells are the first to attend the early phase of events in inflammatory response to SCI. Those pilot cells are seen in the first 12-24 hours and disappear about 3-5 days. The neutrophil accumulation and activation are steered by many cytokines such as TNF-alpha, IL-1 and IL-6. Neutrophils do accompany to the modulation of secondary injury mechanisms via neutrophil proteases and reactive oxygen molecules. When those processes are taken into account, depletion of neutrophils or depression of their functions may derive neuro-protection and neurological healing. Purpose: To investigate the therapeutic and neuroprotective effects of Cyclosporin-A (CSA) on recovery processes using clinical and histopathological tests, which has not been used very frequently in clip compression spinal cord injury (SCI) models. Material and methods: Twenty-four Spraque-Dawley rats were divided into three groups: group 1 [Sham-control, n=8], group 2 [SCI+2 mL saline intramuscular (i.m.), n=8], group 3 [SCI+5 mg/kg CSA (i.p.) 1 h after SCI and for the following three days, n=8]. Rats were evaluated 1st, 3rd, 5th and 10th days after SCI, clinically by Drummond and Moore scale and under light microscopy and by TUNEL test; after scarification on 10th day. Results: Clinical and histopathological results of treatment group were found significantly better than the results of the trauma group. Conclusion: CSA can depress apoptosis and necrosis rates in a statistically significant manner and carry out the statistical difference in clinical results.en_US
dc.identifier.endpage3762en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue8en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3755en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9406
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000403454800078
dc.identifier.urihttps://www.alliedacademies.org/abstract/the-therapeutic-effects-of-cyclosporina-on-experimental-spinal-cord-injury-7192.html
dc.identifier.volume28en_US
dc.identifier.wosWOS:000403454800078en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGezici, Ali Rıza
dc.institutionauthorKılıç, Güven
dc.institutionauthorFırat, Tülin
dc.institutionauthorCancan, Seçkin Emre
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherScientific Publishers Indiaen_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnimalsen_US
dc.subjectCyclosporineen_US
dc.subjectImmunosuppressive Agentsen_US
dc.subjectMotor Activityen_US
dc.subjectSpinal Cord Injuriesen_US
dc.subjectThoracic Vertebraeen_US
dc.titleThe therapeutic effects of cyclosporin-A on experimental spinal cord injury.en_US
dc.typeArticleen_US

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