Effects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated rats

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dc.authorid0000-0001-5608-5742
dc.authorid0000-0003-1719-4924
dc.authorid0000-0002-7168-1507
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorEken, Halil
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2021-06-23T19:18:57Z
dc.date.available2021-06-23T19:18:57Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOxidative stress plays an important role in the pathogenesis of toxic liver diseases and other hepatic alterations including obstruction of bile flow. It has been shown that the gastrointestinal tract and renal tissue is particularly affected during obstruction of bile flow. In this study, we aimed to evaluate the effects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated (BDL) rats. A total of 40 male Sprague-Dawley rats weighing 200-240 g were used in this study. Group 1 (Sham-control, n = 10) rats underwent laparotomy and bile duct was dissected from the surrounding tissue. Group 2 (Dexa-control, n = 10) rats underwent laparotomy and bile duct was dissected from the surrounding tissue. The rats received daily dexamethasone. Group 3 (BDL/Untreated, n = 10) rats were subjected to bile duct ligation and no drug was applied. Group 4 (BDL/Dexa, n = 10) rats received daily dexamethasone by orogastric tube for 14 days after BDL. At the end of the 2-week period, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) were measured and biochemical and histological evaluation were processed. The mean serum bilirubin, liver enzymes, MDA level, and histopathological score significantly decreased and SOD, CAT, and GSH-Px values were significantly increased in group 4 when compared to group 3. Group 3 presented a significant increase in caecal count of E. coli and in aerobe/anaerobe ratio. In group 4, liver was moderately damaged. Ileal biopsies from group 4 demonstrated a significant increase in villus height, total mucosal thickness, and villus density when compared to group 3. Glomerular injury scores (GIS) and arterial injury scores (AIS) in group 3 rats were increased in the juxtamedullary region. In contrast to group 4, tubulo-interstitial lesions were diffuse in group 3 animals. Dexamethasone reduced small bowel and kidney oxidative stress and histological alterations in bile duct-ligated rats with increasing SOD, CAT, and GSH-Px and decreasing MDA levels in rats with obstructed bile duct.en_US
dc.identifier.doi10.1007/s00383-006-1736-2
dc.identifier.endpage718en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue9en_US
dc.identifier.pmid16896816en_US
dc.identifier.scopus2-s2.0-33748415730en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage709en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-006-1736-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5842
dc.identifier.volume22en_US
dc.identifier.wosWOS:000240283300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorÖztürk, Hülya
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile Duct Ligationen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectSmall Bowelen_US
dc.subjectOxidative Stressen_US
dc.subjectDexamethasoneen_US
dc.titleEffects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated ratsen_US
dc.typeArticleen_US

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