Platelet distribution width in young patients with chronic venous insufficiency

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dc.authorid0000-0003-0165-0809en_US
dc.authorid0000-0003-0021-6509en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0003-4709-4705en_US
dc.contributor.authorAldemir, Mustafa
dc.contributor.authorYüksel, Ahmet
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorMetin, Salih
dc.contributor.authorVelioğlu, Yusuf
dc.date.accessioned2023-07-07T06:05:19Z
dc.date.available2023-07-07T06:05:19Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective Platelet distribution width (PDW) has been reported in a wide range of pathological settings. In this study, we aimed to investigate the relationship between PDW and lower extremity chronic venous insufficiency (CVI) by comparing the levels of PDW and other parameters derived from complete blood count (CBC) tests in young individuals with or without lower extremity CVI. Methods This prospective clinical study was conducted between January 2020 and December 2020. A total of 108 patients, 72 patients with lower extremity CVI (study group) and 36 healthy volunteers (control group) were enrolled from the Bursa Yuksek Ihtisas Education Research Hospital and the Bolu Abant Izzet Baysal University Training and Research Hospital. The age range of the participants was between 18 and 50 years old. Participants' baseline clinical features and CBC parameters including PDW, white blood cell, hemoglobin, hematocrit, mean corpuscular volume, red cell distribution width, neutrophil, lymphocyte, platelet count, mean platelet volume, plateletcrit, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were compared between the two groups. Results The groups were statistically similar in terms of baseline clinical features. The median PDW value was significantly higher for the CVI patients relative to the control group (17.6 vs 16.8; p < 0.001). In terms of other CBC parameters, there were no significant differences between the groups. According to ROC analysis, area under the curve of PDW was 0.749 (95% confidence interval: 0.653-0.846 and p < 0.001). If the value of PDW was accepted as 17, it could predict CVI with 76% sensitivity and 59% specificity, whereas a PDW value of 17.5 could predict CVI with 51% sensitivity and 81% specificity. Conclusion Platelet distribution width might be a useful marker to determine an increased inflammatory response and thrombotic status in young patients with CVI.en_US
dc.identifier.citationAldemir, M., Yuksel, A., Inanir, M., Metin, S., Velioglu, Y., Deser, S. B., & Emren, S. V. (2022). Platelet distribution width in young patients with chronic venous insufficiency. Vascular, 30(4), 787-792.en_US
dc.identifier.doi10.1177/17085381211029606
dc.identifier.endpage792en_US
dc.identifier.issn1708-5381
dc.identifier.issn1708-539X
dc.identifier.issue4en_US
dc.identifier.pmid34215170en_US
dc.identifier.scopus2-s2.0-85109107576en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage787en_US
dc.identifier.urihttp://dx.doi.org/10.1177/17085381211029606
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11251
dc.identifier.volume30en_US
dc.identifier.wosWOS:000671409200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYüksel, Ahmet
dc.institutionauthorİnanır, Mehmet
dc.institutionauthorVelioğlu, Yusuf
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofVascularen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlatelet Distribution Widthen_US
dc.subjectComplete Blood Counten_US
dc.subjectChronic Venous Insufficiencyen_US
dc.subjectVolume Indexesen_US
dc.subjectDiseaseen_US
dc.subjectRisken_US
dc.titlePlatelet distribution width in young patients with chronic venous insufficiencyen_US
dc.typeArticleen_US

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