Melatonin protects against epirubicin-induced cardiotoxicity

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dc.authorid0000000215019324
dc.authorid0000-0003-1937-9244
dc.authorid0000-0002-5800-3306
dc.authorid0000-0003-2339-5669
dc.authorid0000-0003-1691-618X
dc.contributor.authorGüven, Aysel
dc.contributor.authorYavuz, Özlem
dc.contributor.authorÇam, Meryem
dc.contributor.authorErcan, Feriha
dc.contributor.authorBukan, Neslihan
dc.contributor.authorÇomunoğlu, Cem
dc.date.accessioned2021-06-23T19:20:36Z
dc.date.available2021-06-23T19:20:36Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractWe investigated the cytoprotective effect of melatonin in epirubicin-induced cardiotoxicity using four experimental groups of mate Wistar rats: untreated control rats, epirubicin-treated rats, epirubicin+melatonin-treated rats, and melatonin-treated rats. We examined the histopathological. and biochemical, effects of melatonin on the epirubicin-induced changes and measured the Levels of the lipid peroxication end-product (malondialdehyde, MDA), an indicator of nitric oxide (NO) synthesis (nitrite/nitrate production), and reduced glutathione (GSH) in the heart. We also studied the extracellular matrix components (fibronectin, laminin) in the heart. Vacuole formation, mitochondrial. deformation and degeneration, and disordered myofibrillary structures were detected ultrastructurally in the epirubicin-treated group. The degeneration was reduced in the heart tissues of the epirubicin+melatonin group. Epirubicin increased the nitrite/nitrate production, but did not change the MDA and GSH levels significantly. Melatonin treatment Lowered the nitrite/nitrate concentrations, while increasing the GSH levels, which exceeded the Levels in epirubicin+melatonin-treated rats. We conclude that the epirubicin increased the nitrozative stress, not the oxidative stress, in heart tissue, and the cardioprotective effect of melatonin was partially attributed to the suppression of epirubicin-induced nitrozative stress. These results suggest that melatonin partially protects against epirubicin-induced cardiotoxicity. (C) 2006 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2006.09.007
dc.identifier.endpage60en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue1en_US
dc.identifier.pmid17109937en_US
dc.identifier.scopus2-s2.0-33846605050en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2006.09.007
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6139
dc.identifier.volume109en_US
dc.identifier.wosWOS:000244594300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüven, Aysel
dc.institutionauthorYavuz, Özlem
dc.institutionauthorCam, Meryem
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpirubicinen_US
dc.subjectCardiotoxicityen_US
dc.subjectNitrite/nitrate productionen_US
dc.subjectHistopathologyen_US
dc.subjectMelatoninen_US
dc.titleMelatonin protects against epirubicin-induced cardiotoxicityen_US
dc.typeArticleen_US

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