Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD)

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dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0001-8397-5636en_US
dc.authorid0000-0001-8078-7074en_US
dc.authorid0000-0002-4130-0494en_US
dc.contributor.authorTopal, Zehra
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorKaradağ, Mehmet
dc.contributor.authorGökçen, Cem
dc.contributor.authorAkkaya, Canan
dc.contributor.authorSarp, Ayşe Sevde
dc.contributor.authorBahsi, İlhan
dc.contributor.authorKılınç, Metin
dc.date.accessioned2023-05-31T07:25:38Z
dc.date.available2023-05-31T07:25:38Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim The aim of the current study is to compare serum B12, folate, and ferritin levels and peripheral inflammatory indicators between children with Autism Spectrum Disorders (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and healthy controls (HC) and to evaluate the correlation of those with symptoms. Materials and Methods A total of 203 children were evaluated (ASD = 72; ADHD = 61; HC = 70). Diagnoses of ASD and ADHD were ascertained according to Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL). Control group was chosen among the healthy children who applied to general pediatrics outpatient clinic. Gilliam Autism Rating Scale-2 is used to assess autistic symptoms and Atilla Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale is used for ADHD symptoms. Results Neutrophil levels (p = 0.014) and neutrophil/lymphocyte ratio (NLR) (p = 0.016) were higher in the ADHD and ASD groups compared to HC. Neutrophil values explained 70.1% of the variance across groups while NLR explained a further 29.9% of the variance. NLR significantly correlated with social interaction problems in ASD (r = 0.26, p = 0.04). There were no significant differences between groups in terms of vitamin B12, folate and ferritin levels. Conclusion Our results may support involvement of inflammation in the underlying pathophysiology of neurodevelopmental disorders. However, these parameters should be analyzed in a wider population to clarify the effect on the etiology and symptomatology of neurodevelopmental disorders.en_US
dc.identifier.citationTopal, Z., Tufan, A. E., Karadag, M., Gokcen, C., Akkaya, C., Sarp, A. S., ... & Kilinc, M. (2022). Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Nordic journal of psychiatry, 76(2), 150-157.en_US
dc.identifier.doi10.1080/08039488.2021.1946712
dc.identifier.endpage157en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue2en_US
dc.identifier.pmid34232109en_US
dc.identifier.scopus2-s2.0-85109977765en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage150en_US
dc.identifier.urihttp://dx.doi.org/10.1080/08039488.2021.1946712
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11017
dc.identifier.volume76en_US
dc.identifier.wosWOS:000670518400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTufan, Ali Evren
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNordic Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutismen_US
dc.subjectAttention Deficit Hyperactivity Disorderen_US
dc.subjectInflammationen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectIron-Deficiencyen_US
dc.subjectSymptom Ratingsen_US
dc.titleEvaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD)en_US
dc.typeArticleen_US

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