Does smoking change expression patterns of the tumor suppressor and DNA repair genes in the prostate gland?

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dc.authorid0000-0003-4096-4261
dc.authorid0000-0003-0580-2144
dc.authorid0000-0001-7965-6229
dc.contributor.authorBoran, Çetin
dc.contributor.authorKandıralı, Engin
dc.contributor.authorYanık, Serdar
dc.contributor.authorAhsen, Hilal
dc.contributor.authorUlukaradağ, Emre
dc.contributor.authorYılmaz, Fahri
dc.date.accessioned2021-06-23T19:45:37Z
dc.date.available2021-06-23T19:45:37Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Somatic mutations can be present in clonally expanded cell populations in nonmalignant tissues, which are detectable at tissue-level resolution. Some of the mutational changes may arise due to smoking. We aimed to find out changes in carcinogenic gene expressions related to smoking in nonmalignant prostate gland epithelia. Materials and methods: The patients who came to the Department of Urology at Abant Izzet Baysal University Medical Faculty from December 2006 to December 2009 for prostate biopsy were questioned for cigarette smoking. The patients were divided into 2 groups, namely, smokers and nonsmokers. Paraffin sections were stained immunohistochemically with p53, PTEN, p16INK4a, MSH2, CHK2, RB, and E-cadherin. Results: Smoking was the main independent factor that had an effect on the immunohistochemical expressions for p53, p16, and PTEN (P = 0.007, P = 0.036, P = 0.015, respectively). Age and inflammation had no statistically significant effects on gene expressions. No difference was found between smokers and nonsmokers for immunohistochemical expressions of E-cadherin, MSH2, RB, and CHK2. Conclusions: Smoking-related carcinogens can alter the expressions of some suppressor genes in a prostate tissue, and these alterations can be determined immunohistochemically. Alterations in these genes in prostate gland epithelia could possibly increase the risk for prostate carcinoma. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.urolonc.2017.03.001
dc.identifier.issn1078-1439
dc.identifier.issn1873-2496
dc.identifier.issue8en_US
dc.identifier.pmid28391998en_US
dc.identifier.scopus2-s2.0-85017134553en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.urolonc.2017.03.001
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9184
dc.identifier.volume35en_US
dc.identifier.wosWOS:000407786400020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBoran, Çetin
dc.institutionauthorKandıralı, Engin
dc.institutionauthorYanık, Serdar
dc.institutionauthorAhsen, Hilal
dc.institutionauthorUlukaradağ, Emre
dc.institutionauthorYılmaz, Fahri
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologic Oncology-Seminars And Original Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Canceren_US
dc.subjectSmokingen_US
dc.subjectSuppressor Geneen_US
dc.subjectDNA Repair Geneen_US
dc.titleDoes smoking change expression patterns of the tumor suppressor and DNA repair genes in the prostate gland?en_US
dc.typeArticleen_US

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