Association between fragmented QRS complexes and left-ventricular dysfunction in anabolic androgenic steroid users

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dc.authorid0000-0002-2159-064Xen_US
dc.authorid0000-0003-1784-3584en_US
dc.contributor.authorKaya, Ülker
dc.contributor.authorEren, Hayati
dc.contributor.authorÖcal, Lütfi
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorBalaban, İsmail
dc.date.accessioned2021-06-23T19:54:15Z
dc.date.available2021-06-23T19:54:15Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Anabolic androgen steroid (AS) use has adverse effects on left ventricular functions, such as fibrosis development. Fragmented QRS is an important marker of myocardial fibrosis, while speckle-tracking echocardiographyis a method used to show subclinical left ventricle dysfunction. In this study, we examined the the ability of fQRS + to detect left ventricle fibrosis by speckle tracking echocardiography (STE) in AS users. Methods: The study included a total of 181 healthy athletes. Athletes were divided into two groups as AS users (n = 89) and non-AS users (n = 92). Then, athletes using AS were divided into two groups as fQRS+ (n = 52) and fQRS- (n = 37). In both groups, the arithmetic mean of three images was used to obtain the left ventricle global longitudinal strain (LV-GLS). The E/SRe ratio was also calculated and analysed. Results: There were significant differences between the AS users and non-AS users in terms of, E/SRe (55.7 +/- 17.9 vs 50.3 +/- 14.8; p = 0.015), LV-GLS (23.1 +/- 1.9 vs 24.0 +/- 1.7; p = 0.001), and fQRS (18.5% vs 6%; p = 0.005). When subgroup analysis was performed, both LV-GLS and E/SRivr were found to be poor in the fQRS + group. When multiple linear regression analysis was performed, we determined fQRS as an independent predictor for LV-GLS and E/SRivr ratio. Conclusion: In conclusion, our study demonstrated that fQRS is a parameter that can beused to determine left ventricle subclinical systolic and diastolic dysfunction in AS users. It can be used for cessation of drug use, especially in long-term use.en_US
dc.identifier.doi10.1080/00015385.2019.1682339
dc.identifier.endpage253en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue3en_US
dc.identifier.pmid31663816en_US
dc.identifier.scopus2-s2.0-85074947033en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://doi.org/10.1080/00015385.2019.1682339
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10476
dc.identifier.volume75en_US
dc.identifier.wosWOS:000538281800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFragmented QRSen_US
dc.subjectAnabolic Androgenic Steroiden_US
dc.subjectSpeckle Tracking Echocardiographyen_US
dc.subjectLeft Ventricular Functionsen_US
dc.titleAssociation between fragmented QRS complexes and left-ventricular dysfunction in anabolic androgenic steroid usersen_US
dc.typeArticleen_US

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