Distinct and mutually exclusive Ca2+ flux-and adenylyl cyclase-inducing gene expression profiles of G-protein-coupled receptors on human antigen-specific B cells

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dc.authorid0009-0007-1971-8513
dc.authorid0000-0001-6985-9436
dc.authorid0000-0001-8020-019X
dc.contributor.authorChang, Iris
dc.contributor.authorKaushik, Abhinav
dc.contributor.authorSatitsuksanoa, Pattraporn
dc.contributor.authorYang, Minglin
dc.contributor.authorBuergi, Laura
dc.contributor.authorSchneider, Stephan R.
dc.contributor.authorBabayev, Huseyn
dc.date.accessioned2024-09-25T20:01:35Z
dc.date.available2024-09-25T20:01:35Z
dc.date.issued2023
dc.departmentBAİBÜ, Lisansüstü Eğitim Enstitüsü, Sağlık Bilimleri, Mikrobiyoloji Ana Bilim Dalı en_US
dc.description.abstractB cells play an essential role in allergies by producing allergen-specific IgE, which is a prerequisite for allergen-induced degranu-lation of mast cells (MCs) and basophils. MCs, basophils, dendriticcells and bacteria are capable of secreting inflammatory mediatorsincluding histamine.1 Histamine is a bioactive amine that exerts itsfunction through binding to histamine receptors (HRs), which are7-transmembrane G-protein-coupled receptors (GPCRs). Histaminecan regulate its function through four receptors (HR1-HR4), in whichligation of histamine with HR1 can trigger Ca 2+ mobilization, whereasHR2 stimulates and increases cAMP concentrations. 2 Interestingly,HRH1 and HRH2 genes can show mutually exclusive expression pat-tern in B cells, with a differential antibody response as demonstratedin the clones.
dc.description.sponsorshipSwiss National Science Foundation [310030-201053/320030-159870, 310030-156823, 310030_189334/1]; Sean N Parker Center for Allergy and Asthma Research at Stanford University; Christine Kuhne-Center for Allergy Research and Education (CK-CARE); Promedica Stiftung; GSK; Novartis; NIAID [U19AI104209, U01AI140498, R01AI140134]; Sean N. Parker Center for Allergy and Asthma Research at Stanford University; Swiss National Science Foundation (SNF) [310030_201053] Funding Source: Swiss National Science Foundation (SNF)en_US
dc.description.sponsorshipM. A. has received research support from the Swiss National Science Foundation No. 310030-201053/320030-159870 and the Sean N Parker Center for Allergy and Asthma Research at Stanford University. C. A. A. is employed by the Swiss Institute of Allergy and Asthma Research, University of Zurich; has research grants from the Swiss National Science Foundation No. 310030-156823, and the Christine Kuhne-Center for Allergy Research and Education (CK-CARE). W.V. received research grant from Promedica Stiftung. M.S. received research grants from the Swiss National Science Foundation (No. 310030_189334/1) and the GSK, and Novartis. K.N. has received the funding from NIAID grants U19AI104209, U01AI140498, and R01AI140134 and the Sean N. Parker Center for Allergy and Asthma Research at Stanford University.en_US
dc.identifier.doi10.1111/all.15858
dc.identifier.endpage3019en_US
dc.identifier.issn0105-4538
dc.identifier.issn1398-9995
dc.identifier.issue11en_US
dc.identifier.pmid37615338en_US
dc.identifier.scopus2-s2.0-85168666707en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3016en_US
dc.identifier.urihttps://doi.org/10.1111/all.15858
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14216
dc.identifier.volume78en_US
dc.identifier.wosWOS:001082653700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBabayev, Huseyn
dc.institutionauthorid0000-0001-6985-9436
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAllergyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectB Cells
dc.subjectAllergies
dc.subjectMast Cells
dc.subjectMobilization
dc.subjectAntibody Response
dc.subjectProtein
dc.titleDistinct and mutually exclusive Ca2+ flux-and adenylyl cyclase-inducing gene expression profiles of G-protein-coupled receptors on human antigen-specific B cellsen_US
dc.typeLetteren_US

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