Could zonulin and presepsin be biomarkers and therapeutic targets for acute myocarditis?

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dc.authorid0000-0001-8923-8709en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0002-3183-5815en_US
dc.authorid0000-0002-4297-1820en_US
dc.authorid0000-0001-6560-8031en_US
dc.authorid0000-0002-9008-6631en_US
dc.contributor.authorToprak, Kenan
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorMemioğlu, Tolga
dc.contributor.authorKaplangöray, Mustafa
dc.contributor.authorPalice, Ali
dc.contributor.authorTaşcanov, Mustafa Beğenç
dc.date.accessioned2024-07-29T10:59:40Z
dc.date.available2024-07-29T10:59:40Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The diagnosis of acute myocarditis is usually made with clinical and laboratory parameters. This can sometimes be mixed up with diseases that have similar clinical features, making the diagnosis difficult. Therefore, the use of more specific biomarkers, in addition to the classically used biomarkers such as troponin, will accelerate the diagnosis. In addition, these biomarkers may help us to understand the mechanism of myocarditis development and thus predict unpredictable clinical outcomes.Objective: This study aims to reveal the possible relationship between intestinal permeability and acute myocarditis.Methods: In this study, we wanted to evaluate serum levels of zonulin and presepsin in 138 consecutive subjects, including 68 patients with myocarditis and another 70 as the control group, matched for age, gender, and cardiovascular risk factors. P-values <0.05 were considered to be statistically significant.Results: Compared to the control group, zonulin and presepsin were significantly higher in the patient group with myocarditis (p < 0.001, for all). Zonulin levels were positively correlated with presepsin, peak CK-MB, and peak troponin levels (r = 0.461, p < 0.001; r = 0.744, p < 0.001; r = 0.627, p < 0.001; respectively). In regression analysis, presepsin and zonulin were determined as independent predictors for myocarditis (OR 1.002, 95% CI 1.001-1.003, p = 0.025; OR 12.331, 95% CI 4.261-35.689; p < 0.001; respectively). The predictive value of acute myocarditis of presepsin and zonulin in ROC curve analysis was statistically significant (p < 0.001, for both).Conclusion: This study showed that zonulin and presepsin could be biomarkers that can be used in the diagnosis of myocarditis, and they can also be therapeutic targets by shedding light on the developmental mechanism of myocarditis.en_US
dc.identifier.citationToprak, K., Inanır, M., Memioğlu, T., Kaplangoray, M., Palice, A., & Tascanov, M. B. (2023). Could Zonulin and Presepsin Be Biomarkers and Therapeutic Targets for Acute Myocarditis?. Arquivos Brasileiros de Cardiologia, 120, e20230017.en_US
dc.identifier.doi10.36660/abc.20230017
dc.identifier.endpage10en_US
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.issue8en_US
dc.identifier.pmid37556677en_US
dc.identifier.scopus2-s2.0-85167531398en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.36660/abc.20230017
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12282
dc.identifier.volume120en_US
dc.identifier.wosWOS:001048992400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİnanır, Mehmet
dc.institutionauthorMemioğlu, Tolga
dc.language.isoenen_US
dc.publisherArquivos Brasileiros Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros de Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkersen_US
dc.subjectMyocarditisen_US
dc.subjectPermeabilityen_US
dc.subjectIntestinal Permeabilityen_US
dc.subjectIn-Vitroen_US
dc.subjectDiagnosisen_US
dc.titleCould zonulin and presepsin be biomarkers and therapeutic targets for acute myocarditis?en_US
dc.typeArticleen_US

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