Effect of sex steroids on colonic distension-induced delay of gastric emptying in rats

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dc.authorid0000-0003-0791-0165en_US
dc.authorid0000-0002-5794-709Xen_US
dc.authorid0000-0001-6990-185X
dc.contributor.authorGünal, Ömer
dc.contributor.authorBozkurt, Ayhan
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorSungur, Mustafa
dc.contributor.authorYeğen, Berrak Ç.
dc.date.accessioned2021-06-23T19:17:52Z
dc.date.available2021-06-23T19:17:52Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Aim: The objective of the present study was to examine the effect of gonadal hormones on gastric motor response to non-noxious and noxious stimuli of colonic distension. Methods: Male Wistar albino rats were used. Under ketamine anesthesia some rats underwent castration (n = 24), while the rest of the rats were sham-operated (n = 67) and divided into different groups (n = 7-8 per group). On the 15th day of surgery, liquid gastric emptying studies were commenced. Results: Non-noxious (P < 0.05) or noxious (P < 0.01) colonic distension inhibited gastric emptying rate. Estradiol pretreatment (20 mug/kg per day, for 5 days, s.c.) inhibited gastric motility, while estradiol pretreatment or castration of the rats prior to noxious distension prevented the delay in gastric emptying. In contrast, blockade of testosterone receptors had no effect on the delay in gastric emptying induced by either modes of distension. Conclusions: The results suggest that sex steroids have a modulatory role on the feedback control of gastric motility induced by noxious colonic distension.en_US
dc.identifier.doi10.1111/j.1440-1746.2004.03409.x
dc.identifier.endpage981en_US
dc.identifier.issn0815-9319
dc.identifier.issue9en_US
dc.identifier.pmid15304112en_US
dc.identifier.scopus2-s2.0-4544229511en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage975en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1746.2004.03409.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5571
dc.identifier.volume19en_US
dc.identifier.wosWOS:000223217000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünal, Ömer
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Gastroenterology And Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCastrationen_US
dc.subjectCologastric Reflexen_US
dc.subjectSex Steroidsen_US
dc.subjectViscerovisceral Reflexen_US
dc.titleEffect of sex steroids on colonic distension-induced delay of gastric emptying in ratsen_US
dc.typeArticleen_US

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