Increased whole blood viscosity is associated with primary idiopathic complete atrioventricular block and poor clinical outcomes in these patients

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dc.authorid0000-0001-8923-8709en_US
dc.authorid0000-0002-4297-1820en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0002-3183-5815en_US
dc.contributor.authorToprak, Kenan
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorPalice, Ali
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorMemioğlu, Tolga
dc.contributor.authorKök, Zafer
dc.date.accessioned2024-06-07T10:49:11Z
dc.date.available2024-06-07T10:49:11Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: Complete atrioventricular block is most commonly caused by age-related degeneration and fibrosis in the cardiac conduction system and is called primary idiopathic complete atrioventricular (iCAVB). Although many factors affect this situation, which increases with age in the cardiac conduction system, the relationship between whole blood viscosity (WBV) and iCAVB has not been clarified until now. In this study, we aim to reveal the relationship between iCAVB and WBV. METHODS AND RESULTS: 141 patients with dual-chamber permanent pacemaker implanted for iCAVB and 140 ageand sex-matched subjects were included in this study. The WBV values of the study groups were compared in both high shear rate (HSR) and low shear rate (LSR). Both WBV at HSR and WBV at LSR were significantly higher in the iCAVB group compared to the control group (16.11 [15.14-16.89] vs 14.40 [13.62-15.58]; 39.82 [17.43-55.23] vs 1.38 [-13.14-26.73]; p < 0.001, respectively). The patient population was followed up for an median of 38 months for all-cause mortality. Higher mortality rates were found in higher WBV at HSR and WBV at LSR (p < 0.001,for both). CONCLUSIONS: In this study, WBV was found to be an independent predictor for iCAVB, and in these patients WBV was associated with poor clinical outcomes.en_US
dc.identifier.citationToprak, K., Kaplangoray, M., Palice, A., İnanır, M., Memioğlu, T., Kök, Z., ... & Demirbağ, R. (2023). Increased whole blood viscosity is associated with primary idiopathic complete atrioventricular block and poor clinical outcomes in these patients. Clinical Hemorheology and Microcirculation, 84(2), 141-151.en_US
dc.identifier.doi10.3233/CH-221596
dc.identifier.endpage151en_US
dc.identifier.issn1386-0291
dc.identifier.issn1875-8622
dc.identifier.issue2en_US
dc.identifier.pmid36683503en_US
dc.identifier.scopus2-s2.0-85167997817en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage141en_US
dc.identifier.urihttp://dx.doi.org/10.3233/CH-221596
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12209
dc.identifier.volume84en_US
dc.identifier.wosWOS:001035843300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİnanır, Mehmet
dc.institutionauthorMemioğlu, Tolga
dc.language.isoenen_US
dc.publisherIOS Pressen_US
dc.relation.ispartofClinical Hemorheology and Microcirculationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary Idiopathic Complete Atrioventricular Blocken_US
dc.subjectWhole Blood Viscosityen_US
dc.subjectHigh Shear Rateen_US
dc.subjectLow Shear Rateen_US
dc.subjectArterial Stiffnessen_US
dc.subjectPlasmaen_US
dc.titleIncreased whole blood viscosity is associated with primary idiopathic complete atrioventricular block and poor clinical outcomes in these patientsen_US
dc.typeArticleen_US

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