Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma

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dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorYağcı, Ramazan
dc.contributor.authorAtış, Ömer
dc.contributor.authorKaradağ, Remzi
dc.contributor.authorAkbaş, Ali
dc.contributor.authorHepşen, İbrahim F.
dc.date.accessioned2021-06-23T19:27:52Z
dc.date.available2021-06-23T19:27:52Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The aim of this study was to establish the antioxidant status and oxidative stress in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEG). Methods: Serum levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) as indicators of antioxidant status; and total oxidant status (TOS), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) as indicators of oxidative stress were measured from the blood samples of patients with POAG (n = 23), PEG (n = 24) and healthy control subjects (n = 19) by spectrophotometry. Results: Mean TAC level was 0.6 +/- 0.1 mmol/L in the POAG group; 0.5 +/- 0.1 mmol/L in the PEG group and 1.2 +/- 0.3 mmol/L in the control group (p = 0.001). Mean SOD level was 13 +/- 0.5 mg/L in the POAG group, 11.6 +/- 0.2 mg/L in the PEG group and 9.4 +/- 0.6 mg/L in the control group (p = 0.001). Mean TOS level was 19.6 +/- 2.6 mu mol/L in the POAG group, 21.2 +/- 4.2 mu mol/L in the PEG group and 15.1 +/- 7 mu mol/L in the control group (p = 0.001). Mean NO level was 74.3 +/- 14.4 mu mol/L in the POAG group, 66.1 +/- 8.1 mu mol/L in the PEG group and 62.3 +/- 13.5 mu mol/L in the control group (p = 0.005). Mean PC level was 641.5 +/- 102.5 nmol/mg in the POAG group, 988.3 +/- 214.7 nmol/mg in the PEG group and 654.4 +/- 150.7 nmol/mg in the control group (p = 0.001). Mean MDA level was 1.9 +/- 0.2 mu mol/L in the POAG group, 1.7 +/- 0.4 mu mol/L in the PEG group and 1.1 +/- 0.2 mu mol/L in the control group (p = 0.001). Conclusion: The findings of the present study are potentially of significance and add to the growing body of evidence for oxidative stress in POAG and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of POAG and PEG.en_US
dc.identifier.doi10.3109/02713683.2011.584370
dc.identifier.endpage718en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue8en_US
dc.identifier.pmid21780920en_US
dc.identifier.scopus2-s2.0-79960739926en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage713en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2011.584370
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6907
dc.identifier.volume36en_US
dc.identifier.wosWOS:000293015300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdurmuş, Mesut
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Statusen_US
dc.subjectOxidative Stressen_US
dc.subjectOpen Angle Glaucomaen_US
dc.subjectPseudoexfoliative Glaucomaen_US
dc.subjectProtein Carbonylen_US
dc.titleAntioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucomaen_US
dc.typeArticleen_US

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