Use of N-butyl cyanoacrylate in nasal septoplasty: histopathological evaluation using rabbit nasal septum model

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dc.authorid0000-0003-2293-5520
dc.authorid0000-0003-2696-8274
dc.contributor.authorAksoy, Mehmet Fadlullah
dc.contributor.authorYılmaz, Fahrettin
dc.contributor.authorYıldırım, Yavuz Selim
dc.contributor.authorGideroğlu, Kaan
dc.contributor.authorTatar, Z.
dc.date.accessioned2021-06-23T19:26:56Z
dc.date.available2021-06-23T19:26:56Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: This study was designed to investigate the effects of the tissue adhesive N-butyl cyanoacrylate on nasal septal tissues after septal surgery in a rabbit model. Methods: Forty-two adult New Zealand rabbits were randomly divided into three groups (14 in each group): septoplasty alone, septoplasty plus N-butyl cyanoacrylate, and controls. The open approach was used to explore the nasal septum. After raising mucoperichondrial and mucoperiosteal flaps on both sides of the septum, the septum was detached from the nasal floor in the septoplasty alone and septoplasty plus N-butyl cyanoacrylate groups. In the septoplasty plus N-butyl cyanoacrylate group, the mucoperichondrial and mucoperiosteal flaps were fixed to the septum and the septum was fixed lateral to the nasal spine using N-butyl cyanoacrylate; in the septoplasty alone group, the septum was packed with Merocel. In the control group, no further septal surgery was performed after flap elevation. Animals were observed for bleeding and haematoma formation over the first 24 hours. Seven animals in each group were used to evaluate early histopathological effects on the septal tissues, at four weeks post-operatively; the other seven in each group were used to evaluate late effects, at 12 weeks. Results: Haematoma formation was observed in 10 animals in the septoplasty alone group, in four animals in the control group, and in only one animal in the septoplasty plus N-butyl cyanoacrylate group. The difference in haematoma incidence between the septoplasty alone and the septoplasty plus N-butyl cyanoacrylate groups was significant (p = 0.000). Histopathological evaluation revealed no significant difference between the groups as regards granulation tissue formation at week four versus week 12; however, there was a significant difference between the septoplasty plus N-butyl cyanoacrylate group and the control groups as regards inflammation at week 12 (p = 0.038). There was a significant difference between the septoplasty plus N-butyl cyanoacrylate group and the septoplasty alone group as regards the composition of the bone cartilage junction zone at week four (p = 0.001). There was also a significant difference between the septoplasty plus N-butyl cyanoacrylate group and the control group as regards the cellular structure of new cartilage formation at week 12 (p = 0.004). Conclusions: in this rabbit septoplasty model, N-butyl cyanoacrylate appeared to be an effective nasal tissue adhesive, with a low complication rate.en_US
dc.identifier.doi10.1017/S0022215110000095
dc.identifier.endpage758en_US
dc.identifier.issn0022-2151
dc.identifier.issn1748-5460
dc.identifier.issue7en_US
dc.identifier.pmid20193100en_US
dc.identifier.scopus2-s2.0-77955848020en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://doi.org/10.1017/S0022215110000095
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6693
dc.identifier.volume124en_US
dc.identifier.wosWOS:000280119700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fahrettin
dc.institutionauthorGideroğlu, Kaan
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal Of Laryngology And Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasal Septumen_US
dc.subjectSeptoplastyen_US
dc.subjectWound Healingen_US
dc.subjectTissue Adhesiveen_US
dc.subjectCyanoacrylateen_US
dc.titleUse of N-butyl cyanoacrylate in nasal septoplasty: histopathological evaluation using rabbit nasal septum modelen_US
dc.typeArticleen_US

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