Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis

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dc.authorid0000-0003-0727-1797en_US
dc.authorid0000-0003-3341-9898
dc.contributor.authorSünnetçioğlu, Mahmut
dc.contributor.authorMengeloğlu, Zafer
dc.contributor.authorBaran, Ali İrfan
dc.contributor.authorKarahocagil, Mustafa
dc.contributor.authorTosun, Mehmet
dc.contributor.authorKüçükbayrak, Abdülkadir
dc.contributor.authorAkdeniz, Hayrettin
dc.date.accessioned2021-06-23T19:36:11Z
dc.date.available2021-06-23T19:36:11Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA. Methods: A total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA levels using ADMA ELISA kit (Immunodiagnostik AG, Bensheim, Germany). Results: ADMA levels were found to be significantly higher in the patients group than the controls (p < 0.001). In addition, ADMA levels were found to be positively associated with sedimentation rates (R = 0.413; p = 0.026), and inversely associated with international normalized ratio (INR) levels (R = -0.46; p = 0.011). A cut-off value of 0.475 of ADMA had a sensitivity of 74.3%, specificity of 77.8%, and accuracy of 75.5% in the diagnosis of CA. Conclusion: Although the exact mechanism still remains unclear, ADMA levels could be related to immune activation in CA. In addition, these data might suggest the higher ADMA levels in patients could be due to the perivascular inflammation and vasculitis in CA.en_US
dc.identifier.doi10.1186/1476-0711-13-12
dc.identifier.issn1476-0711
dc.identifier.pmid24669818en_US
dc.identifier.scopus2-s2.0-84899051559en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/1476-0711-13-12
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7945
dc.identifier.volume13en_US
dc.identifier.wosWOS:000334615100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengeloğlu, Zafer
dc.institutionauthorTosun, Mehmet
dc.institutionauthorKüçükbayrak, Abdülkadir
dc.institutionauthor
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofAnnals Of Clinical Microbiology And Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDimethylarginineen_US
dc.subjectInfectionen_US
dc.subjectAnthraxen_US
dc.subjectVasculitisen_US
dc.titleAsymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysisen_US
dc.typeArticleen_US

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