Determination of antimicrobial and antimutagenic properties of some Schiff bases

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dc.authorid0000-0001-7100-9318en_US
dc.authorid0000-0002-6309-8936en_US
dc.authorid0000-0002-2795-8863en_US
dc.authorid0000-0002-1316-4835en_US
dc.authorid0000-0002-8445-5082en_US
dc.contributor.authorÖğütcü, Hatice
dc.contributor.authorMeral, Seher
dc.contributor.authorÇeker, Selçuk
dc.contributor.authorAğar, Ayşen Alaman
dc.contributor.authorAğar, Güleray
dc.date.accessioned2023-07-14T12:14:14Z
dc.date.available2023-07-14T12:14:14Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn this study, we aimed to investigate for the first time antimicrobial and antimutagenic activities new two Schiff bases, obtained from a primary amine (p-toluidine, o-toluidine) and an aldehyde (Helicin). Synthesized compounds characterized with elemental analysis, fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometry. H-1-C-13 nuclear magnetic resonance spectroscopy. Antimutagenic activity was evaluated by micronuclei assay. Antimicrobial activity of Schiff bases have been demonstrated against pathogenic four Gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermis, Micrococcus luteus, Bacillus cereus) and four Gram-negative bacteria (Pseudumonas aeroginosa, Salmonella typhi H, Brucella abortus, Escherichia coli) and two yeasts (Candida albicans and Saccharomyces cerevisiae). The results showed that both Schiff bases have antimutagenic activity. Especially, high concentration (20 mu M) of (E)-2-(hydroxymethyl)-6-(2-((p-tolylimino)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol (Compound I) and (E)-2-(hydroxymethyl)-6-(2-((o-tolylimino)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol (Compound II) have strong antimutagenic activity against aflatoxin B-1. On the other hand, both of studied compounds were found effective against pathogenic bacteria and yeasts. Compound I exhibited more activity against P. aeroginosa, S aureus, S.typhi H and C. albicans comparable to Compound II and standard antibiotics. Additionally, Compound II showed better inhibitory activity than Compound I against Candida albicans and Br. Abortus. Therefore, these compounds can be used in phytotherapeutic due to theirs antimutagenic and antimicrobial activities.en_US
dc.identifier.citationOgutcu, H., Meral, S., Ceker, S., Agar, A. A., & Agar, G. (2021). Determination of antimicrobial and antimutagenic properties of some Schiff bases. Anais da Academia Brasileira de Ciências, 93.en_US
dc.identifier.doi10.1590/0001-3765202120191432
dc.identifier.endpage8en_US
dc.identifier.issn0001-3765
dc.identifier.issn1678-2690
dc.identifier.issue3en_US
dc.identifier.pmid34287457en_US
dc.identifier.scopus2-s2.0-85110518575en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1590/0001-3765202120191432
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11293
dc.identifier.volume93en_US
dc.identifier.wosWOS:000677487800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇeker, Selçuk
dc.language.isoenen_US
dc.publisherAcad Brasileira De Cienciasen_US
dc.relation.ispartofAnais Da Academia Brasileira De Cienciasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Microbial Activityen_US
dc.subjectElemental Analysisen_US
dc.subjectGenotoxicityen_US
dc.subjectMechanismen_US
dc.subjectComplexesen_US
dc.subjectCR(III)en_US
dc.titleDetermination of antimicrobial and antimutagenic properties of some Schiff basesen_US
dc.typeArticleen_US

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