Evaluation of patients with nasal polyps about the possible association of desmosomal junctions, RORA and PDE4D gene

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-4229-6589
dc.authorid0000-0003-4097-9754
dc.contributor.authorApuhan, Tayfun
dc.contributor.authorGepdiremen, Selma
dc.contributor.authorArslan, Ali Osman
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2021-06-23T19:34:13Z
dc.date.available2021-06-23T19:34:13Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVES: Nasal polyposis is chronic inflammatory disease of the nasal mucosa of the nose and sinuses, often associated with chronic non-allergic rhinitis, aspirin intolerance and non-allergic asthma. The etiology of nasal polyposis is unknown. Multiple factors contribute to the development of nasal polyps including genetic predisposition. PATIENTS AND METHODS: This study was conducted on patients applied due to nasal polyps. Blood samples were collected peripheral vein and stored at 4 C until analysis for DNA extraction. Genomic DNA was extracted from peripheral blood by a standard method, samples were studied in real time PCR. All patients were evaluated about the possible association of DSG1 (rs7236477-G, 96 rxn), DSG3 (rs1941184-C, 96 rxn), PDE4D (rs1588265) and RORA (rs11071559) gene. RESULTS: 32 patients (17 male, 15 female) with nasal polyposis were included to the study. The mean age was 34.9 +/- 17.7 years, ranging between 18 and 55 years. Control group was consisted with 50 healthy volunteers without a history of nasal polyp. DSG1, DSG3 and RORA values of the study group were not statistically different from control group (p > 0.05). PDE4D values of the study group were significantly different from control group (p < 0.05). CONCLUSIONS: Multiple factors contribute to the pathogenesis of nasal polyps including genetic predisposition. The PDE4D family has gained interest in the complex pathogenesis of nasal polyposis. This is likely linked to the mucosal inflammatory response.en_US
dc.identifier.endpage2683en_US
dc.identifier.issn1128-3602
dc.identifier.issue19en_US
dc.identifier.pmid24142618en_US
dc.identifier.startpage2680en_US
dc.identifier.urihttps://www.europeanreview.org/wp/wp-content/uploads/2680-2683.pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7429
dc.identifier.volume17en_US
dc.identifier.wosWOS:000326270500020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorApuhan, Tayfun
dc.institutionauthorGepdiremen, Selma
dc.institutionauthorArslan, Ali Osman
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNasal Polyposisen_US
dc.subjectDesmosomal Junctionsen_US
dc.subjectRORAen_US
dc.subjectPDE4Den_US
dc.subjectChronic Sinusitisen_US
dc.titleEvaluation of patients with nasal polyps about the possible association of desmosomal junctions, RORA and PDE4D geneen_US
dc.typeArticleen_US

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