Could hemogram parameters be predictors of dementia in elderly patients?

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dc.authorid0000-0002-0202-8555
dc.authorid0000-0003-1996-1568
dc.contributor.authorDağıstan, Emine
dc.contributor.authorCoşgun, Zeliha
dc.date.accessioned2021-06-23T19:51:41Z
dc.date.available2021-06-23T19:51:41Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To study red cell distribution width (RDW), RDW to platelet ratio (RPR) and mean platelet volume to platelet ratio (MPR), novel inflammatory markers of routine hemogram, of patients with or without dementia, according to the grade of the disease established by Fazekas's score in magnetic resonance imaging (MRI). Methods: A total of 1342 cases that undergone cranial MRI study were retrospectively analyzed. Patients without a previous stroke and over 45 years were enrolled in the study. Demographic and laboratory characteristics of the participants were obtained from institutional computerized database. Subcortical and periventricular white matter were evaluated in axial FLAIR images according to Fazekas's grading scale. Univariate and multivariate analysis were performed for assessing the predictors of Fazekas's grading scale. Results: MPR of Fazekas 0, Fazekas 1, Fazekas 2 and Fazekas 3 groups were 3, 3, 4 and 3%, respectively. MPR difference between study groups was not significant (p = .32). RPR of Fazekas 0, Fazekas 1, Fazekas 2 and Fazekas 3 groups were 6, 7, 7 and 7%, respectively. RPR difference between study groups was significant (p < .001). Conclusion: We suggest that increased RDW and RPR values may indicate higher Fazekas's score and dementia in cranial imaging studies. The radiologist should pay particular attention in interpretation of cranial MRI of these patients.en_US
dc.identifier.doi10.1080/13685538.2019.1618821
dc.identifier.endpage197en_US
dc.identifier.issn1368-5538
dc.identifier.issn1473-0790
dc.identifier.issue3en_US
dc.identifier.pmid31134837en_US
dc.identifier.scopus2-s2.0-85069535206en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.1080/13685538.2019.1618821
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10030
dc.identifier.volume22en_US
dc.identifier.wosWOS:000470412900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDağıstan, Emine
dc.institutionauthorCoşgun, Zeliha
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofAging Maleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDementiaen_US
dc.subjectFazekas's Scoreen_US
dc.subjectRed Cell Distribution Widthen_US
dc.subjectInflammationen_US
dc.subjectRed Cell Distribution Width to Platelet Ratioen_US
dc.titleCould hemogram parameters be predictors of dementia in elderly patients?en_US
dc.typeArticleen_US

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