The effects of ivabradine on left atrial electromechanical function in patients with systolic heart failure

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dc.authorid0000-0002-6913-9073
dc.authorid0000-0002-3426-1212
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorÖztürk, Selçuk
dc.contributor.authorErdem, Fatma Hizal
dc.contributor.authorErdem, Alim
dc.contributor.authorAyhan, Selim
dc.contributor.authorDönmez, İbrahim
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2021-06-23T19:43:07Z
dc.date.available2021-06-23T19:43:07Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim Heart rate (HR) reduction with ivabradine improves left ventricle filling by the prolongation of the diastolic time and increases stroke volume. But, it remains unclear what ivabradine's effect is on atrial conduction time and atrial mechanical functions. The aim of our study was to evaluate in stable outpatients with systolic heart failure (HF) the 3 months effect of ivabradine on atrial conduction time and mechanical functions. Method We evaluated prospectively 43 (31 males, 12 females) patients with HF. Before and after treatment, all patients were evaluated by transthoracic M mode, two dimensional (2D), pulsed-wave (PW), continuous wave (CW), color flow and tissue Doppler imaging (TDI), and LA volumes were obtained apical four-chamber views by a disc's method. LA maximum volume (Vmax) at the end-systolic phase, LAminimum volume (Vmin) at the end-diastolic phase, and LA volume before atrial systole (Vp) were evaluated. The LA function parameters were calculated as follows: LA passive emptying volume=Vmax -Vp; LA passive emptying fraction = [(Vmax -Vp)/Vmax] x100%, LA active emptying volume= Vp-Vmin; LA active emptying fraction=[(Vp-Vmin)/Vp] x100%. Results Thirty men and 13 women with mean +/- SD age of 63.9 +/- 10.1 years were included in this study. Resting heart rate was significantly reduced after ivabradine treatment. There were no significantly difference in LVEF, and E/A before and after ivabradine treatment. LA diameter and Vmin were similar before and after ivabradine treatment (p= 0.793 and p = 0.284). However, Vmax and Vp were significantly decreased after ivabradine treatment (p = 0.040 and p = 0.012). Moreover, LA active emptying volume and LA active emptying fraction were significantly decreased after ivabradine treatment (p= 0.030 and p= 0.008). The PA lateral, septal, and tricuspid durations were significantly reduced after ivabradine treatment (p< 0.001, p< 0.001, and p= 0.002, respectively). Interatrial electromechanical delay and right intraatrial electromechanical delay were significantly decreased after ivabradine treatment (33.7 +/- 12.7 vs 26.2 +/- 10.1, p = 0.001; and 14.1 +/- 6.1 vs 9.2 +/- 6.8, p< 0.001). Conclusions The present study demonstrated that adding ivabradine to the standard therapy reduced HR and improves significantly LA electrical and mechanical functions in systolic HF patients.en_US
dc.identifier.doi10.1007/s10840-016-0129-2
dc.identifier.endpage258en_US
dc.identifier.issn1383-875X
dc.identifier.issn1572-8595
dc.identifier.issue3en_US
dc.identifier.pmid27039084en_US
dc.identifier.scopus2-s2.0-84962142239en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.1007/s10840-016-0129-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8697
dc.identifier.volume46en_US
dc.identifier.wosWOS:000387109800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Serkan
dc.institutionauthorÖztürk, Selçuk
dc.institutionauthorErdem, Fatma Hizal
dc.institutionauthorErdem, Alim
dc.institutionauthorAyhan, Selim
dc.institutionauthorDönmez, İbrahim
dc.institutionauthorYazıcı, Mehmet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Interventional Cardiac Electrophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIvabradineen_US
dc.subjectAtrial Conduction Timeen_US
dc.subjectAtrial Mechanical Functionen_US
dc.subjectSystolic Heart Failureen_US
dc.titleThe effects of ivabradine on left atrial electromechanical function in patients with systolic heart failureen_US
dc.typeArticleen_US

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