Serum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation

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dc.authorid0000-0001-5207-5846en_US
dc.authorid0000-0001-6595-7493en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0002-9653-9048en_US
dc.authorid0000-0002-4601-3937en_US
dc.contributor.authorYılmaz, Mehmet Fatih
dc.contributor.authorAcar, Emrah
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorKarabay, Can Yücel
dc.contributor.authorİzgi, İbrahim Akın
dc.date.accessioned2023-07-17T12:07:12Z
dc.date.available2023-07-17T12:07:12Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction Data regarding the possible role of heparanase (HPA) in the occurrence of left atrial/left atrial appendage (LA/LAA) thrombus in patients with atrial fibrillation (AF) is lacking. The goal of the present study was to assess the association between plasma levels of HPA and LA/LAA thrombus in AF. Methods A total of 687 patients with nonvalvular AF (NVAF) without anticoagulation therapy were included from January 2016 to June 2019. Serum HPA analysis was performed with a commercially available human ELISA kit. Logistic regression models were used to test for association. Results Serum HPA levels were significantly higher in patients with LA/LAA thrombus than in those without LA/LAA thrombus (270.8 [193.4 +/- 353.2] pg/mL vs 150.3 [125.2 +/- 208.4] pg/mL; P < 0.001). In multivariate analysis, serum HPA remained a significantly independent predictor of LA/LAA thrombus (odds ratio 1.674, 95% confidence interval [CI] 1.339-2.289, P < 0.001). In the receiver operating characteristic (ROC) curve analysis, HPA showed a predictive value with an area under the curve (AUC) of 0.757 (95% CI 0.652-0.810, P < 0.001). The optimal cutoff level for HPA predicting LA/LAA thrombus was 210.7 pg/mL, with a sensitivity of 74.3% and a specificity of 64.8%. Conclusion An elevated HPA level was associated with the presence of LA/LAA thrombus in patients with AF. HPA might portend the risk for the prothrombotic state in AF patients.en_US
dc.identifier.citationYilmaz, M. F., Acar, E., Inanir, M., Karabay, C. Y., & Izgi, I. A. (2022). Serum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation. Herz, 47(3), 251-257.en_US
dc.identifier.doi10.1007/s00059-021-05052-z
dc.identifier.endpage257en_US
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.issue3en_US
dc.identifier.pmid34351431en_US
dc.identifier.scopus2-s2.0-85111870642en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage251en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s00059-021-05052-z
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11300
dc.identifier.volume47en_US
dc.identifier.wosWOS:000681564300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherURBAN & VOGELen_US
dc.relation.ispartofHerzen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeparanaseen_US
dc.subjectLeft Atriumen_US
dc.subjectProcoagulanten_US
dc.subjectThrombusen_US
dc.subjectEchokardiografieen_US
dc.subjectProcoagulant Activityen_US
dc.titleSerum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillationen_US
dc.typeArticleen_US

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