Can topical agents (arnica and mucopolysaccharide polysulfate) reduce postoperative pain, edema and trismus following mandibular third molar surgery?

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dc.authorid0000-0001-6270-5901
dc.contributor.authorAkay, Neşet
dc.contributor.authorŞanal, Koray Onur
dc.date.accessioned2024-09-25T20:01:32Z
dc.date.available2024-09-25T20:01:32Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground: Postoperative supplemental maintenance following mandibular third molar surgery remains an area of interest. Purpose: Topical agents can modulate inflammatory processes. The aim of the present study was to determine if topical application of arnica or mucopolysaccharide polysulfate (MPSP) reduces pain, trismus, and edema following the removal of impacted mandibular third molars. Materials and methods: A single center randomized controlled clinical trial was conducted. The patients were randomized into three groups: the control group (standard therapy [ST]: antibiotic + nonsteroidal anti-inflammatory drugs twice a day), the arnica group (arnica + ST), and the MPSP group (MPSP + ST). The patients' pain, trismus, and edema values were measured preoperatively and on postoperative days 1, 3, 5, and 10. Sex, age, and operation time were also included. Analyses included descriptive statistics, analysis of variance, post hoc tests, and determinations of intraclass correlation coefficients. Statistical significance was set at P < .05. Results: Sixty patients with a mean age of 26.98 +/- 10.88 years were included in the study; 55% were females and 45% were males. The mean operation time was 23.8 +/- 3.27 minutes. According to the visual analogue scale scores (in centimeter units), the arnica and MPSP groups felt less pain than the control group until day 5 (0.6 +/- 0.88, 3.75 +/- 1.16, 4.75 +/- 1.29, and 1.05 +/- 1.10, respectively, for the arnica group; 0.35 +/- 0.59, 3.25 +/- 1.62, 5.0 +/- 1.65, and 1.50 +/- 1.32 for the MPSP group; and 1.30 +/- 1.17, 5.75 +/- 1.37, 7.05 +/- 1.10, and 3.15 +/- 1.53 for the control group; P < .05). The trismus was lower on days 1, 3, and 5 in the arnica group (-8.05 +/- 2.82, -12.15 +/- 3.1, and -2.15 +/- 1.81, respectively) than in the control group (-12 +/- 3.82, -15.65 +/- 4.81, and -4 +/- 2.81, respectively) (P < .05). The edema was lower on days 1 and 3 in the MPSP group (0.95 +/- 2.2 and 1.75 +/- 3.7, respectively) than in the control group (2.45 +/- 0.9 and 3.6 +/- 0.8, respectively) (P < .05). Arnica and MPSP had similar pain-relieving action, but arnica was more effective at reducing trismus, while MPSP was more effective at reducing edema. Conclusions: Topical application of arnica or MPSP may have a beneficial effect on relieving pain 5 days after surgery, but arnica was also effective at reducing trismus, while MPSP was also effective at reducing edema. Both arnica and MPSP reduced postoperative sequelae.en_US
dc.identifier.doi10.1016/j.joms.2023.10.003
dc.identifier.endpage121en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue1en_US
dc.identifier.pmid37913818en_US
dc.identifier.scopus2-s2.0-85175725330en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2023.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14187
dc.identifier.volume82en_US
dc.identifier.wosWOS:001165909500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkay, Neşet
dc.institutionauthorŞanal, Koray Onur
dc.institutionauthorid0000-0001-6270-5901
dc.language.isoenen_US
dc.publisherW.B. Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Oral And Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectDouble-Blind
dc.subjectPlacebo
dc.subjectComplications
dc.subjectMontana
dc.subjectMethylprednisolone
dc.titleCan topical agents (arnica and mucopolysaccharide polysulfate) reduce postoperative pain, edema and trismus following mandibular third molar surgery?en_US
dc.typeArticleen_US

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