Antiinflammatory properties of antiLy6G antibody disappear during magnetic field exposure in rats with carrageenan induced acute paw inflammation

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dc.authorid0000-0002-5926-9210en_US
dc.authorid0000-0001-8312-5156en_US
dc.contributor.authorMert, Tufan
dc.contributor.authorMetin, Tuba Özcan
dc.contributor.authorŞahin, Mehmet
dc.contributor.authorYaman, Selma
dc.date.accessioned2021-06-23T19:54:08Z
dc.date.available2021-06-23T19:54:08Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAntiinflammatory properties of pulsed magnetic field (PMF) treatments or administration of antiLy6G antibody have been previously reported. In this study, we hypothesized that, the combination of PMF treatments and antiLy6G administration may synergistically potentiate their antiinflammatory actions. The effects of the combination of PMF treatments and antiLy6G administration were investigated by examining the inflammatory signs, histopathological properties of the inflamed site, and measuring the macrophage inflammatory protein-1 alpha (MIP-1 alpha/CCL3) and myeloperoxidase (MPO) levels of inflamed paw tissues in rats with carrageenan-induced acute paw inflammation. In this present study, PMF treatments alone or administration of antiLy6G alone ameliorated the acute inflammation. However, their combination exacerbated the inflammatory signs, hyperalgesia, allodynia, edema and fever, and aggravated the inflammatory conditions by excessive infiltration of inflammatory cells to the inflamed site. These opposing effects of the combined treatments may correlate with enhanced levels of MIP-1 alpha and MPO in inflamed paws. Present results indicated that the combination of the PMF treatments and antiLy6G administration may not provide additional benefits and may actually cause an aggravation of the acute inflammatory process. Findings may also suggest that during neutrophil or immune cell-targeted treatments for inflammatory states, magnetic field exposure may cause unexpected negative consequences.en_US
dc.identifier.doi10.1007/s00210-020-01925-y
dc.identifier.endpage2115en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue11en_US
dc.identifier.pmid32592030en_US
dc.identifier.scopus2-s2.0-85086881344en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2107en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-020-01925-y
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10435
dc.identifier.volume393en_US
dc.identifier.wosWOS:000543584900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMert, Tufan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulsed Magnetic Fielden_US
dc.subjectAntiLy6G Antibodyen_US
dc.subjectMIP-1 Alphaen_US
dc.subjectInflammationen_US
dc.subjectRatsen_US
dc.titleAntiinflammatory properties of antiLy6G antibody disappear during magnetic field exposure in rats with carrageenan induced acute paw inflammationen_US
dc.typeArticleen_US

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