Altered plasma levels of arginine metabolites in depression

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dc.authorid0000-0002-1422-1600
dc.contributor.authorÖzden, Arısoy
dc.contributor.authorAngelos, Halaris
dc.contributor.authorFeyza, Arıcıoğlu
dc.contributor.authorElizabeth, Wild
dc.contributor.authorJohn, Piletz
dc.date.accessioned2021-06-23T19:54:58Z
dc.date.available2021-06-23T19:54:58Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractL-Arginine pathway metabolites appear to play differential roles in the pathogenesis of major depressive disorder (MDD). Studies have revealed an antidepressant and anxiolytic effect of agmatine and putrescine. Possible mechanisms of these effects include inhibition of nitric oxide synthase and N-methyl-D-aspartate receptors. The present study sought to determine whether MDD is associated with altered levels of arginine metabolites and whether these metabolites are associated with depression, anxiety and stress severity. Seventy seven MDD patients 21-65 years of age with a minimum score of 18 on the Hamilton Depression Scale, and 27 age and sex matched healthy controls (HC) were included. Patients with uncontrolled physical diseases, abnormal routine lab tests, other psychiatric diagnoses, or under psychotropic medication were excluded. HC subjects were recruited from the community. Rating instruments included Hamilton Depression and Anxiety Scales, Beck Depression and Anxiety Inventory and Perceived Stress Scale. Fasting blood was drawn between 8:30 and 11:00 a.m. and High Performance Liquid Chromatography (HPLC) was used to measure plasma arginine metabolites. ADMA (Asymmetrical dimethylarginine) and putrescine were significantly lower while SDMA (Symmetric dimethylarginine), agmatine and ornithine were significantly higher in MDD patients (p(<)0.05). Depression, anxiety and stress severity were negatively correlated with ADMA and putrescine (p(<)0.05). Stress was positively correlated with citrulline, NOHA (N-omega-hydroxy-nor-1-arginine), SDMA, agmatine and ornithine (p(<)0.05). Lower putrescine levels predicted depression diagnosis (p = 0.039) and depression severity (p = 0.003). Low ADMA level predicted depression severity as well. Arginine pathway metabolites are associated with the pathophysiology of depression. Putrescine may be a biomarker to predict MDD.en_US
dc.identifier.doi10.1016/j.jpsychires.2019.10.004
dc.identifier.endpage28en_US
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid31629205en_US
dc.identifier.scopus2-s2.0-85073212381en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2019.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10694
dc.identifier.volume120en_US
dc.identifier.wosWOS:000500381100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzden, Arısoy
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor depressionen_US
dc.subjectStressen_US
dc.subjectArginine Metabolitesen_US
dc.subjectAgmatineen_US
dc.subjectPutrescineen_US
dc.subjectADMA (Asymmetric Dimethyl Arginine)en_US
dc.titleAltered plasma levels of arginine metabolites in depressionen_US
dc.typeArticleen_US

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