Comparison of World Health Organization 2000/2004 and World Health Organization 2010 classifications for gastrointestinal and pancreatic neuroendocrine tumors

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dc.authorid0000-0002-6661-1002en_US
dc.authorid0000-0001-8590-4831
dc.authorid0000-0001-8967-9061
dc.authorid0000-0001-8076-7911
dc.authorid0000-0002-9843-9825
dc.contributor.authorPaşaoğlu, Esra
dc.contributor.authorDursun, Nevra
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorHacıhasanoğlu, Ezgi
dc.contributor.authorBehzatoğlu, Kemal
dc.date.accessioned2021-06-23T19:42:11Z
dc.date.available2021-06-23T19:42:11Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractGastroenteropancreatic neuroendocrine tumors (GEPNETs) were divided into 4 groups based on tumor diameter and stage in World Health Organization (WHO) 2000/2004 classification as well-differentiated endocrine tumor benign (WDETB), well-differentiated endocrine tumor with uncertain behavior (WDETUB), well-differentiated endocrine carcinoma (WDEC), and poorly differentiated endocrine carcinoma (PDEC). World Health Organization 2000/2004 was not widely accepted because of stage-related classification and the category of "uncertain behavior." The European NET Society proposed a grading classification and site-specific staging system in 2010. Gastroenteropancreatic NETs were divided into 3 groups as NET grade 1 (G1), NET grade 2 (G2), and neuroendocrine carcinoma (NEC) grade 3 (G3) based on mitoses and the Ki-67 index. We evaluated 63 GEPNET cases according to both classifications. We compared two classifications and the tumor groups in terms of prognostic parameters (diameter, mitosis, Ki-67 index, angioinvasion, perineural invasion, necrosis, and metastasis) and pathologic stage. All 14 cases diagnosed as PDEC were included in the NEC G3 according to WHO 2010. Seventeen cases were diagnosed as WDETB, 9 as WDETUB, and 23 as WDEC. There was statistically significant difference between these groups in terms of all prognostic parameters except for necrosis, mitosis, Ki-67 index, and grade. All WDETB cases, 89% of WDETUBs, and 87% of WDECs were included in the NET G1. There were 45 cases evaluated as NET G1 and 4 cases as NET G2 according to WHO 2010. Metastasis and perineural invasion were more common in NET G2, no significant differences in other parameters. In conclusion, WHO 2010 is easier to use, whereas WHO 2000/2004 shows higher correlation with prognosis. However, it includes benign and uncertain behavior categories, although small tumors with low proliferative activity can also cause metastases. All GEPNETs should be considered potentially malignant (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.anndiagpath.2015.01.001
dc.identifier.endpage87en_US
dc.identifier.issn1092-9134
dc.identifier.issn1532-8198
dc.identifier.issue2en_US
dc.identifier.pmid25702616en_US
dc.identifier.scopus2-s2.0-84925114551en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1016/j.anndiagpath.2015.01.001
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8382
dc.identifier.volume19en_US
dc.identifier.wosWOS:000351808500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAnnals Of Diagnostic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuroendocrine Tumoren_US
dc.subjectGastrointestinal Tracten_US
dc.subjectPancreasen_US
dc.subjectClassificationen_US
dc.titleComparison of World Health Organization 2000/2004 and World Health Organization 2010 classifications for gastrointestinal and pancreatic neuroendocrine tumorsen_US
dc.typeArticleen_US

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