Plasma levels of vasoactive neuropeptides in pediatric patients with migraine during attack and attack-free periods

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dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0001-6002-052Xen_US
dc.contributor.authorHancı, Fatma
dc.contributor.authorKılınç, Yasemin Baranoğlu
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTuray, Sevim
dc.contributor.authorDilek, Mustafa
dc.contributor.authorKabakuş, Nimet
dc.date.accessioned2021-06-23T19:55:15Z
dc.date.available2021-06-23T19:55:15Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Increasing evidence suggests that vasoactive neuropeptides such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide are involved in the pathophysiology of migraine in adults, but their role in pediatric migraineurs remains unclear. We prospectively investigated plasma levels of these vasoactive neuropeptides in pediatric migraine patients without aura and compared the results with those of age-matched healthy controls. Methods Thirty-eight children aged 6-18 years with migraine without aura and 20 age-matched control subjects were included in the study. Neuropeptides in plasma samples from the controls, and in either the ictal or interictal periods in pediatric migraine without aura, were measured using ELISA. Results PACAP-38 and vasoactive intestinal peptide levels in both ictal and interictal plasma were higher in the patients with pediatric migraine without aura than in the controls (p < 0.001), although calcitonin gene-related peptide and substance P levels remained unchanged. Otherwise, no significant difference was determined between ictal and interictal periods in terms of all neuropeptide levels. Conclusions This study demonstrates increased plasma PACAP-38 and vasoactive intestinal peptide levels, but not calcitonin gene-related peptide and substance P levels, in pediatric patients with migraine during both attack and attack-free periods. The study findings suggest that PACAP-38 and vasoactive intestinal peptide may be implicated in the pathophysiology of migraine, particularly in pediatric migraineurs.en_US
dc.identifier.doi10.1177/0333102420957588
dc.identifier.endpage175en_US
dc.identifier.issn0333-1024
dc.identifier.issn1468-2982
dc.identifier.issue2en_US
dc.identifier.pmid32903061en_US
dc.identifier.scopus2-s2.0-85090430793en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://doi.org/10.1177/0333102420957588
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10763
dc.identifier.volume41en_US
dc.identifier.wosWOS:000567847200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılınç, Erkan
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofCephalalgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPediatric migraineen_US
dc.subjectCGRPen_US
dc.subjectPACAP-38en_US
dc.subjectSPen_US
dc.subjectVIPen_US
dc.titlePlasma levels of vasoactive neuropeptides in pediatric patients with migraine during attack and attack-free periodsen_US
dc.typeArticleen_US

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