Comparative analysis of thiol-disulfide homeostasis dynamics between elective cesarean section and uncomplicated vaginal delivery: Insights into perinatal oxidative balance

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dc.authorid0000-0002-6338-1408
dc.authorid0000-0002-7284-6887
dc.authorid0000-0003-0434-3206
dc.authorid0000-0002-1703-0690
dc.authorid0000-0002-2996-3236
dc.contributor.authorÇendek, Büşra Demir
dc.contributor.authorBayraktar, Bilge
dc.contributor.authorTonyalı, Nazan Vanlı
dc.contributor.authorÇakır, Betül Tokgöz
dc.contributor.authorAlışık, Murat
dc.contributor.authorKoç, Sevgi
dc.contributor.authorErel, Özcan
dc.date.accessioned2024-09-25T19:58:54Z
dc.date.available2024-09-25T19:58:54Z
dc.date.issued2024
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: Thiols are organic compounds containing sulfhydryl groups that exert antioxidant effects via dynamic thiol-disulfide homeostasis. The shift towards disulfide indicates the presence of an oxidative environment. Different modes of delivery can affect thiol-disulfide homeostasis. Accordingly, we planned this research to evaluate the effects of the mode of delivery on thiol-disulfide homeostasis in both maternal serum and fetal cord blood samples. PATIENTS AND METHODS: We conducted a prospective case -control study involving two groups: vaginal delivery (n=50) and elective cesarean section (CS) (n=45). The vaginal delivery group exclusively comprised uncomplicated term deliveries, while the CS group included pregnant individuals with scheduled cesarean deliveries due to the absence of spontaneous labor onset. Maternal serum and fetal cord blood samples were collected, and thiol-disulfide exchanges were analyzed using an automated method capable of measuring both aspects of the thiol-disulfide balance. RESULTS: The levels of native thiol (-SH) and total thiol in both maternal serum and fetal cord blood samples were significantly higher in the vaginal delivery group than those in the CS group. An important discovery of our study was that fetal cord disulfide (-SS) level, which may reflect oxidative stress, was higher in newborns born via vaginal delivery when examined alone. However, in both maternal and fetal cord blood, the combined ratios, SS/SH ratio (%), SS/ Total thiol ratio (%), and SH/Total thiol ratio (%) were observed to be similar between the groups in both maternal and fetal cord blood. It was observed that as the mother's weight gained during pregnancy increased, SS/SH and SS/total thiol increased (positive correlation), while SH/total thiol decreased (negative correlation). CONCLUSIONS: Our results showed that the dynamic thiol-disulfide homeostasis was greatly influenced by the way of delivery and supported the idea that vaginally-delivered infants may have more oxidative stress.en_US
dc.identifier.endpage1479en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid38436181en_US
dc.identifier.scopus2-s2.0-85186730752en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1471en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13816
dc.identifier.volume28en_US
dc.identifier.wosWOS:001179105400008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlışık, Murat
dc.institutionauthorid0000-0003-0434-3206
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectMode of Deliveryen_US
dc.subjectCesarean Sectionen_US
dc.subjectVaginal Deliveryen_US
dc.subjectThiolsen_US
dc.subjectDisulfidesen_US
dc.subjectOxidative Stressen_US
dc.titleComparative analysis of thiol-disulfide homeostasis dynamics between elective cesarean section and uncomplicated vaginal delivery: Insights into perinatal oxidative balanceen_US
dc.typeArticleen_US

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