Neutrophil-lymphocyte ratio as a predictor of recurrence and progression in patients with high-grade pT1 bladder cancer

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dc.authorid0000-0003-1944-7059en_US
dc.authorid0000-0003-3662-9399en_US
dc.authorid0000-0002-4313-8478
dc.authorid0000-0001-8590-4831
dc.authorid0000-0003-1698-8263
dc.authorid0000-0001-7858-0672
dc.contributor.authorÖzyalvaçlı, Mehmet Emin
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorKocaaslan, Ramazan
dc.contributor.authorÇeçen, Kürşat
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorKemahlı, Eray
dc.contributor.authorGücük, Adnan
dc.date.accessioned2021-06-23T19:42:17Z
dc.date.available2021-06-23T19:42:17Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: We investigated the value of the preoperative neutrophil-lymphocyte ratio (NLR) in predicting recurrence and progression of high-grade pT1 non-muscle-invasive tumour in patients with bladder cancer during a 5-year follow-up period. Methods: We retrospectively reviewed data of 1100 patients with bladder cancer; these patients underwent transurethral resection and were monitored at multiple centres from 2008 to 2013. In total, 166 consecutive and newly diagnosed patients with high-grade pT1 tumours were included in this study. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. Results: Of the 166 patients, 152 were male. The patients were evaluated as two separate groups in terms of recurrence and progression. The mean follow-up period was 24.2 months (interquartile range 13.8-36.6 months). A statistically significant difference was found between recurrence and tumour size (p = 0.001), number of tumours (p < 0.001), NLR (p < 0.001), and smoking (p = 0.007). No statistically significant correlation was found between NLR and progression. According to receiver operating characteristic (ROC) analysis, the optimum cut-off value for the NLR was >= 2.43 (74% sensitivity, 60% specificity, p < 0.001; area under the curve [AUC] 0.687, 95% confidence interval [CI] 0.607-0.767). Multivariate logistic regression analysis determined that the following factors were independent predictors of recurrence in patients with high-grade pT1 non-muscle-invasive bladder cancer: tumour number (OR 5.32, 95% CI 2.10-12.90), NLR of >= 2.43 (OR 2.587; 95% CI 1.156-5.789), and smoking (OR 4.17, 95% CI 1.31-13.21). Conclusion: A high preoperative NLR may play an important role in predicting recurrence of superficial transitional cell type high-grade pT1 bladder tumours. Prospective studies are required to validate the role of NLR as a prognostic marker in high-grade pT1 bladder tumours.en_US
dc.identifier.doi10.5489/cuaj.2523
dc.identifier.endpageE131en_US
dc.identifier.issn1911-6470
dc.identifier.issn1920-1214
dc.identifier.issue3-4en_US
dc.identifier.pmid25844098en_US
dc.identifier.scopus2-s2.0-84925328515en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE126en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8426
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4374998&blobtype=pdf
dc.identifier.volume9en_US
dc.identifier.wosWOS:000355755100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzyalvaçlı, Mehmet Emin
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorKemahlı, Eray
dc.institutionauthorGücük, Adnan
dc.language.isoenen_US
dc.publisherCanadian Urological Associationen_US
dc.relation.ispartofCuaj-Canadian Urological Association Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBladder Canceren_US
dc.subjectNeutrophil-lymphocyte Ratio
dc.titleNeutrophil-lymphocyte ratio as a predictor of recurrence and progression in patients with high-grade pT1 bladder canceren_US
dc.typeArticleen_US

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