Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in patients with aggressive periodontitis

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dc.authorid0000-0003-4104-6462en_US
dc.authorid0000-0001-6100-322X
dc.contributor.authorGünpınar, Şadiye
dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorDündar, Niyazi
dc.date.accessioned2021-06-23T19:45:33Z
dc.date.available2021-06-23T19:45:33Z
dc.date.issued2017
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including 80 AgP and 80 age- and gender-matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP, and 80 H. Volume of GCF was measured by Periotron 8000 (R), and enzyme-linked immunosorbent assay was used to assess MCP-1 levels. RESULTS: Compared to H controls, all clinical parameters and total amounts (pg 30 s(-1)) of MCP-1 were significantly higher in subjects with LAgP and GAgP (P < 0.05). Although concentrations of GCF MCP-1 did not differ between LAgP and GAgP (P > 0.05), total amounts of MCP-1 were higher in GAgP than LAgP (P < 0.05). CONCLUSION: It can be concluded that the total amount of MCP-1 level in GCF may be a potential determinant in AgP subjects. Increased MCP-1 levels in line with the degree of periodontal destruction in GAgP patients reveal that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.en_US
dc.identifier.doi10.1111/odi.12658
dc.identifier.endpage769en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue6en_US
dc.identifier.pmid28231622en_US
dc.identifier.scopus2-s2.0-85017028373en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://doi.org/10.1111/odi.12658
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9171
dc.identifier.volume23en_US
dc.identifier.wosWOS:000407267500012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünpınar, Şadiye
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAggressive Periodontitisen_US
dc.subjectEnzyme-Linked Immunosorbent Assayen_US
dc.subjectGingival Crevicular Fluiden_US
dc.subjectMonocyte Chemoattractant Protein-1en_US
dc.titleGingival crevicular fluid levels of monocyte chemoattractant protein-1 in patients with aggressive periodontitisen_US
dc.typeArticleen_US

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