The impact of the D727e polymorphism has no significant role in multi nodular goiter

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dc.authorid0000-0002-2408-5294en_US
dc.authorid0000-0003-4318-9619
dc.authorid0000-0002-3487-1264
dc.authorid0000-0003-4488-3186
dc.contributor.authorTuğ, Esra
dc.contributor.authorŞengül, Neriman
dc.contributor.authorAydın, Hatip
dc.contributor.authorYılmaz, Edip Erdal
dc.date.accessioned2021-06-23T19:33:55Z
dc.date.available2021-06-23T19:33:55Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractInteractions between individual genetic and environ-mental factors determine the onset of the multi nodular goiter (MNG). The thyroid-stimulating hormone receptor (TSHR) gene is a convincing candidate gene in the pathogenesis of certain thyroid diseases including MNG. We investigated the codon 727 polymorphism (p.Asp727Glu, p.D727E) of the human TSHR gene using the polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP) methods in 31 Turkish patients with MNG and in 30 control subjects, aiming to evaluate the relationship between this polymorphism and MNG. After genomic DNA isolation, PCR amplification was performed using a pair of primers in exon 10 of the TSHR gene that contains the p.D727E polymorphism and digested by theNlaIII (Hin1II) restriction enzyme. We found the CC and CG genotype incidence for the patient group to be 0.71 and 0.29, respectively, and for the control group to be 0.8 and 0.2, respectively. No statistically significant difference was found between the genotype and allele distribution of both groups (p = 0.417 and p = 0.449, respectively). However, the polymorphism is significantly correlated with the low serum level of the TSH (p = 0.047). These results suggest that the p.D727E polymorphism of the TSHR gene may not contribute to the pathogenesis of nontoxic MNG diseases.en_US
dc.identifier.doi10.2478/bjmg-2013-0009
dc.identifier.endpage71en_US
dc.identifier.issn1311-0160
dc.identifier.issue2en_US
dc.identifier.pmid24052734en_US
dc.identifier.scopus2-s2.0-84879577759en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.2478/bjmg-2013-0009
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7274
dc.identifier.volume15en_US
dc.identifier.wosWOS:000318406300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Edip Erdal
dc.institutionauthorŞengül, Neriman
dc.language.isoenen_US
dc.publisherMacedonian Acad Sciences Artsen_US
dc.relation.ispartofBalkan Journal Of Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMulti nodular goiter (MNG)en_US
dc.subjectCodon 727 apolymorphismen_US
dc.subjectp.D727Een_US
dc.subjectThyroid-stimulating Hormone Receptor (TSHR) Geneen_US
dc.titleThe impact of the D727e polymorphism has no significant role in multi nodular goiteren_US
dc.typeArticleen_US

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