The effect of kisspeptin on spermatogenesis and apoptosis in rats

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dc.authorid0000-0002-9313-2920
dc.authorid0000-0001-5912-9392
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorFırat, Tülin
dc.contributor.authorKükner, Aysel
dc.contributor.authorÖzoğul, Candan
dc.contributor.authorTöre, Fatma
dc.date.accessioned2021-06-23T18:40:28Z
dc.date.available2021-06-23T18:40:28Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/aim: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. Materials and methods: Four groups were formed as follows: control, Kiss-10 50 nmol administration for 1 day, Kiss-10 administration for 13 days, and one last group kept for 7 days following Kiss-10 applied for 13 days. Testicular tissues were stained with hematoxylineosin, periodic acid Schiff, Masson trichrome staining, terminal deoxynucleotidyl transferased UTP nick-end labeling, and Ki-67 immune staining. Serum testosterone levels were determined. Results: Serum testosterone level increased following acute application, while it was reduced by chronic treatment. Spermatogenic cells as stained by Ki-67 and TUNEL increased in the treated groups compared to the controls. Following a 7-day rest after treatment, a decrease in testosterone levels and Ki-67–stained cell numbers and an increase in TUNEL-stained cells were observed. Leydig cells showed increased vacuolization in the Kiss-1 group. Leydig cell vacuolization continued in the Kiss (13) group and was reduced in the Kiss (13 + 7) group. Conclusion: Kiss-10 increased spermatogenic cell proliferation, while testosterone level and proliferation decreased and apoptosis increased during the waiting period.en_US
dc.identifier.endpage342en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid28263511en_US
dc.identifier.scopus2-s2.0-85014085077en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage334en_US
dc.identifier.trdizinid253165en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpVek1UWTFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3119
dc.identifier.volume47en_US
dc.identifier.wosWOS:000395632600048en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorFırat, Tülin
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKisspeptinen_US
dc.subjectSpermatogenesis
dc.subjectApoptosis
dc.subjectLeydig Cells
dc.titleThe effect of kisspeptin on spermatogenesis and apoptosis in ratsen_US
dc.typeArticleen_US

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