Retinal morphological changes during the two years of follow-up in parkinson's disease

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dc.authorid0000-0003-4221-2506
dc.contributor.authorAtum, Mahmut
dc.contributor.authorDemiryürek, Bekir Enes
dc.date.accessioned2021-06-23T18:57:08Z
dc.date.available2021-06-23T18:57:08Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The study aims to investigate the relationship between the progression of idiopathic Parkinson's disease (IPD) and retinal morphology. Methods: The study was carried out with 23 patients diagnosed with early-stage IPD (phases 1 and 2 of the Hoehn and Yahr scale) and 30 age-matched healthy controls. All patients were followed up at least two years, with 6-month intervals (initial, 6th month, 12th month, 18th month, and 24th month), and detailed neurological and ophthalmic examinations were performed at each follow-up. Unified Parkinson's Disease Rating Scale part III (UPDRS Part III) scores, Hoehn and Yahr (H&Y) scores, bestcorrected visual acuity (BCVA), intraocular pressure (IOP) measurement, central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness were analyzed at each visit. Results: The average age of the IPD and control groups was 43.96 ± 4.88 years, 44.53 ± 0.83 years, respectively. The mean duration of the disease in the IPD group was 7.48 ± 5.10 months at the start of the study (range 0-16). There was no statistically significant difference in BCVA and IOP values between the two groups during the two-year follow-up period (p> 0.05, p> 0.05, respectively). Average and superior quadrant RNFL thicknesses were statistically different between the two groups at 24 months and there was no significant difference between other visits (p = 0.025, p=0.034, p> 0.05, respectively). There was no statistically significant difference in CMT between the two groups during the follow-up period (p> 0.05). Conclusion: Average and superior quadrant RNFL thicknesses were significantly thinning with the progression of IPD.en_US
dc.identifier.doi10.21203/rs.3.rs-17217/v1
dc.identifier.endpage63en_US
dc.identifier.issn0019-1442
dc.identifier.issue1-2en_US
dc.identifier.pmid33497054en_US
dc.identifier.scopus2-s2.0-85100458376en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.18071/isz.74.0057
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5137
dc.identifier.volume74en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemiryürek, Bekir Enes
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofIdeggyogyaszati Szemleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMacular Thicknessen_US
dc.subjectOptic Coherence Tomographyen_US
dc.subjectParkinson’s Diseaseen_US
dc.subjectRetinal Nerve Fiber Layeren_US
dc.titleRetinal morphological changes during the two years of follow-up in parkinson's diseaseen_US
dc.typeArticleen_US

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