Retinal morphological changes during the two years of follow-up in parkinson's disease
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NLM (Medline)
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The study aims to investigate the relationship between the progression of idiopathic
Parkinson's disease (IPD) and retinal morphology.
Methods: The study was carried out with 23 patients diagnosed with early-stage IPD (phases 1 and 2 of
the Hoehn and Yahr scale) and 30 age-matched healthy controls. All patients were followed up at least
two years, with 6-month intervals (initial, 6th month, 12th month, 18th month, and 24th month), and
detailed neurological and ophthalmic examinations were performed at each follow-up. Unified
Parkinson's Disease Rating Scale part III (UPDRS Part III) scores, Hoehn and Yahr (H&Y) scores, bestcorrected visual acuity (BCVA), intraocular pressure (IOP) measurement, central macular thickness (CMT)
and retinal nerve fiber layer (RNFL) thickness were analyzed at each visit.
Results: The average age of the IPD and control groups was 43.96 ± 4.88 years, 44.53 ± 0.83 years,
respectively. The mean duration of the disease in the IPD group was 7.48 ± 5.10 months at the start of
the study (range 0-16). There was no statistically significant difference in BCVA and IOP values between
the two groups during the two-year follow-up period (p> 0.05, p> 0.05, respectively). Average and superior
quadrant RNFL thicknesses were statistically different between the two groups at 24 months and there
was no significant difference between other visits (p = 0.025, p=0.034, p> 0.05, respectively). There was
no statistically significant difference in CMT between the two groups during the follow-up period (p>
0.05).
Conclusion: Average and superior quadrant RNFL thicknesses were significantly thinning with the
progression of IPD.
Açıklama
Anahtar Kelimeler
Macular Thickness, Optic Coherence Tomography, Parkinson’s Disease, Retinal Nerve Fiber Layer
Kaynak
Ideggyogyaszati Szemle
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
74
Sayı
1-2
