Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats

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dc.authorid0000-0003-1251-3148
dc.authorid0000-0002-4905-219X
dc.authorid0000-0003-3464-3197
dc.authorid0000-0001-9388-501X
dc.authorid0000-0003-0628-9303
dc.contributor.authorTayşi, Seyithan
dc.contributor.authorKeleş, Mevlüt Sait
dc.contributor.authorGümüştekin, Kenan
dc.contributor.authorAkyüz, Mehmet
dc.contributor.authorBöyük, Abdullah
dc.date.accessioned2021-06-23T18:55:11Z
dc.date.available2021-06-23T18:55:11Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: The aim of this study was to evaluate plasma homocysteine (Hcy), malondialdehyde (MDA), glutathione (GSH) levels, glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) activities and liver tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) levels in control and vitamin B6-deficient rats. MATERIALS AND METHODS: Thirty-two male rats with a weight of 65-75 g were used for the experiment. The rats were divided into control (n=16) and vitamin B6-deficient groups. At the end of the experiment, the animals were anesthetized with ketamine-HCl (Ketalar, 20 mg/kg, i.p.), and the blood was collected by cardiac puncture after thoracotomy. Plasma Hcy, pyridoxal phosphate (PLP), liver SAM, SAH levels measured by an isocratic system with high performance liquid chromatography. Plasma GSHPx, GST activities and GSH, MDA levels were carried out using a spectrophotometer. RESULTS: Plasma Hcy, MDA, liver tissue SAH levels were significantly increased, whereas plasma GSH, PLP, liver tissue SAM levels, plasma GST, GSH-Px activities and SAM/SAH ratio were decreased compared to those of control group. CONCLUSIONS: Vitamin B6 deficiency causes an increase in plasma homocysteine levels. Thus, we think that vitamin B6 supplementation could be used for therapeutic purposes in hyperhomocysteinemia condition.en_US
dc.identifier.endpage160en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid25635989en_US
dc.identifier.scopus2-s2.0-84930352385en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage154en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4701
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84930352385&partnerID=40&md5=99d85bca2dfac72f95d6cf5801aa9cb7
dc.identifier.volume19en_US
dc.identifier.wosWOS:000352211700024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGümüştekin, Kenan
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFree Radicalen_US
dc.subjectHomocysteineen_US
dc.subjectPyridoxal-5-Phosphateen_US
dc.subjectS-adenosylhomocysteineen_US
dc.subjectS-adenosylmethionineen_US
dc.subjectVitamin B6-deficiencyen_US
dc.titlePlasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient ratsen_US
dc.typeArticleen_US

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