Can increased intestinal permeability and low-grade endotoxemia be the triggering pathogenesis in isolated coronary artery ectasia

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dc.authorid0000-0003-1784-3584en_US
dc.contributor.authorToprak, Kenan
dc.contributor.authorKaplangöray, Mustafa
dc.contributor.authorAltıparmak, İbrahim Halil
dc.contributor.authorTaşcanov, Mustafa Begenç
dc.contributor.authorGüngören, Fatih
dc.contributor.authorFedai, Halil
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorBiçer, Asuman
dc.contributor.authorDemirbağ, Recep
dc.date.accessioned2023-08-11T09:55:48Z
dc.date.available2023-08-11T09:55:48Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose Isolated coronary artery ectasia (ICAE) is a rare coronary artery disease (CAD) encountered during coronary angiography. Although many mechanisms have been suggested today that may be associated with ICAE, the underlying pathogenesis has not been fully understood. In this study, we aimed to reveal the possible relationship between intestinal permeability and ICAE. Methods Of the 12 850 patients who underwent coronary angiography, 138 consecutive patients with ICAE and 140 age- and sex-matched subjects with normal coronary arteries as the control group and 140 subjects with stenotic CAD were included in the study. Results Serum zonulin and lipopolysaccharide levels were significantly higher in patients with ICAE than in the control group and CAD group. Additionally, zonulin and lipopolysaccharide levels were significantly higher in the CAD group than in the ICAE group. In the correlation analysis, serum zonulin levels were correlated with the mean diameter and length of the ecstatic segment. In multivariate analysis, zonulin and lipopolysaccharide were identified as independent predictors for ICAE. Conclusion These results suggest that there may be a pathophysiological relationship between increased intestinal permeability and ICAE.en_US
dc.identifier.citationToprak, K., Kaplangoray, M., Altiparmak, I. H., Taşcanov, M. B., Güngören, F., Fedai, H., ... & Demirbağ, R. (2023). Can increased intestinal permeability and low-grade endotoxemia be the triggering pathogenesis in isolated coronary artery ectasia?. Coronary Artery Disease, 34(2), 102-110.en_US
dc.identifier.doi10.1097/MCA.0000000000001209
dc.identifier.endpage110en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue2en_US
dc.identifier.pmid36720018en_US
dc.identifier.scopus2-s2.0-85147186934en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage102en_US
dc.identifier.urihttp://dx.doi.org/10.1097/MCA.0000000000001209
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11496
dc.identifier.volume34en_US
dc.identifier.wosWOS:000924066800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectIsolated Coronary Artery Ectasiaen_US
dc.subjectIntestinal Permeabilityen_US
dc.subjectLipopolysaccharideen_US
dc.subjectLow-Grade Endotoxemiaen_US
dc.subjectZonulinen_US
dc.titleCan increased intestinal permeability and low-grade endotoxemia be the triggering pathogenesis in isolated coronary artery ectasiaen_US
dc.typeArticleen_US

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