Outcomes from cyanoacrylate use in tracheal anastomosis in a rat model

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dc.authorid0000-0002-4646-7250
dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorKöybaşı, Serap
dc.contributor.authorSeyhan, Sinan
dc.contributor.authorFırat, Tülin
dc.contributor.authorKazaz, Hasan
dc.date.accessioned2021-06-23T19:37:28Z
dc.date.available2021-06-23T19:37:28Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives We aimed to investigate the histologic effects of N-butyl-2-cyanoacrylate (NBCA) and metacryloxisulfolane (MS) comonomer on tracheal anastomosis in vivo on a rat model of tracheal resection and end-to-end anastomosis. Study Design Animal experiment. Rat model of tracheal resection and end-to-end anastomosis. Setting Animal laboratory. Subjects and Methods Tracheal resection and end-to-end anastomosis were performed in 28 Wistar albino rats. Rats were randomly divided into 2 groups: control (n = 14), in which anastomoses were performed with 8/0 Vicryl, and study (n = 14), in which NBCA and MS comonomer was used in addition to 8/0 Vicryl to perform anastomosis. Seven rats from each group were sacrificed on day 7 and the remaining on day 28 for gross and histologic examination. Results Indurations at the site of anastomoses were detected in all rats of study group. Slight narrowing at the site of anastomosis was observed in 8 rats of the study group and in only 1 of the control group. The difference was significant on day 28 (P = .021). The inflammatory cell infiltration was significantly increased in the study group on day 28 (P = .022). Epithelial regeneration was found to be worse in the study group on day 28 (P = .022). Conclusions The use of NBCA and MS comonomer increased the inflammation in rat tracheal anastomosis with respect to inflammatory cell count and epithelial regeneration. So the use of NBCA and MS comonomer in tracheal surgery cannot be recommended yet in the light of our data.en_US
dc.identifier.doi10.1177/0194599815601986
dc.identifier.endpage821en_US
dc.identifier.issn0194-5998
dc.identifier.issn1097-6817
dc.identifier.issue5en_US
dc.identifier.pmid26340926en_US
dc.identifier.scopus2-s2.0-84946037722en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage815en_US
dc.identifier.urihttps://doi.org/10.1177/0194599815601986
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8165
dc.identifier.volume153en_US
dc.identifier.wosWOS:000364383600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBiçer, Yusuf Özgür
dc.institutionauthorKöybaşı, Serap
dc.institutionauthorFırat, Tülin
dc.institutionauthorSeyhan, Sinan
dc.institutionauthorKazaz, Hasan
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofOtolaryngology-Head And Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyanoacrylateen_US
dc.subjectTracheaen_US
dc.subjectAnastomosisen_US
dc.subjectInflammationen_US
dc.subjectWound Healingen_US
dc.titleOutcomes from cyanoacrylate use in tracheal anastomosis in a rat modelen_US
dc.typeArticleen_US

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