The relationship between fibrosis level and blood neutrophil to lymphocyte ratio in inactive hepatitis B carriers

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dc.authorid0000-0003-3726-5945en_US
dc.authorid0000-0002-6054-9244en_US
dc.contributor.authorYılmaz, Bülent
dc.contributor.authorAydın, Hayrunnisa
dc.contributor.authorCan, Güray
dc.contributor.authorŞentürk, Zeynep
dc.contributor.authorÜstüner, Berna
dc.contributor.authorKurt, Mevlüt
dc.date.accessioned2021-06-23T19:35:16Z
dc.date.available2021-06-23T19:35:16Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim Neutrophil-lymphocyte ratio (NLR) has been used as a simple, affordable, and easily accessible marker to predict prognosis in a variety of inflammatory and neoplastic diseases. However, there are few studies investigating their role in patients with hepatitis B. The aim of this study was to investigate the relationship between NLR and liver fibrosis in patients who were being followed as inactive hepatitis B carriers. Materials and methods The study included 78 patients who were followed for 1 year as inactive hepatitis B carriers. Liver biopsy was performed and the fibrosis scores of the histological activity index were assessed according to the Metavir scoring system. The patients were divided into two groups on the basis of the fibrosis scores: those with a score below 2 and those with a score above 2. In both groups, demographic data such as sex, age, and BMI were similar. The NLR of patients was calculated from blood samples taken at the same time as the biopsy. Results Histopathologic analysis of 78 patients showed that 41 (53%) had fibrosis grade 0-1 and 37 (47%) patients had fibrosis grade greater than 2. According to the biopsy results, there were no cirrhotic patients. NLR was found to be statistically significantly lower in the group with fibrosis grade of at least 2 (1.51 +/- 0.61 vs. 1.79 +/- 0.64, P=0.043). Other biochemical and hematological data were found to be similar in both groups. No correlation was found between laboratory values and NLR. In addition, there was no correlation between NLR with histologic activity. Spearman correlation analysis showed a negative correlation between the fibrosis score and NLR (r=-0.279, P=0.013). Conclusion In inactive hepatitis B carriers, the histological activity index and NLR were found to be correlated negatively. NLR can be used as a predictor of fibrosis in combination with other noninvasive markers. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MEG.0000000000000204
dc.identifier.endpage1328en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue12en_US
dc.identifier.pmid25244413en_US
dc.identifier.scopus2-s2.0-84927694815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1325en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000000204
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7753
dc.identifier.volume26en_US
dc.identifier.wosWOS:000344732600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCan, Güray
dc.institutionauthorKurt, Mevlüt
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal Of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibrosisen_US
dc.subjectHepatitis Ben_US
dc.subjectNeutrophil to Lymphocyte Ratioen_US
dc.titleThe relationship between fibrosis level and blood neutrophil to lymphocyte ratio in inactive hepatitis B carriersen_US
dc.typeArticleen_US

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