Aprotinin ameliorates ischemia/reperfusion injury in a rat hind limb model

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dc.authorid0000-0002-6095-264Xen_US
dc.authorid0000-0002-7832-0499
dc.authorid0000-0002-8259-7896
dc.authorid0000-0002-2106-2329
dc.contributor.authorKöksal, Cengiz
dc.contributor.authorBozkurt, A. Kürşat
dc.contributor.authorŞirin, Gökçe
dc.contributor.authorKonukoğlu, Dildar
dc.contributor.authorÜstündağ, Nil
dc.date.accessioned2021-06-23T19:18:01Z
dc.date.available2021-06-23T19:18:01Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the study was to investigate the protective effect of aprotinin in a rat hind limb ischemia/reperfusion (I/R) model. A well-known antioxidant, a-tocopherol, was also tested for comparison. Ischemia was induced for 4 h by vascular clamping of the iliac arteries of 24 Sprague-Dawley rats, followed by 1 h of reperfusion. Muscle injury was evaluated in three groups: a saline group, an a-tocopherol group and an aprotinin group. Blood pH, pO(2), pCO(2), HCO3, creatine kinase (CPK), lactate dehyrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) as well as muscle TBARS were measured at the end of the reperfusion. Muscle tissue samples were taken for histological examination. alpha-Tocopherol and aprotinin groups showed a significant amelioration of plasma CPK (p=0.002, p=0.002), LDH (p=0.004, p=0.004) and muscle tissue TBARS (p=0.001, p=0.001) compared with the control. Plasma TBARS were significantly lower in the aprotinin group compared with the control (p=0.017). Also, tissue TBARS was significantly lower in the aprotinin group than the a-tocopherol group (p<0.001). Neutrophil infiltration was less prominent in the a-tocopherol and aprotinin groups compared to the control (p=0.006, p=0.001). These results suggest that aprotinin, a potent anti-inflammatory drug, is more useful than a-tocopherol, a powerful antioxidant, for attenuating muscle injury after I/R.en_US
dc.identifier.doi10.1016/j.vph.2004.05.004
dc.identifier.endpage129en_US
dc.identifier.issn1537-1891
dc.identifier.issn1879-3649
dc.identifier.issue4-5en_US
dc.identifier.pmid15607495en_US
dc.identifier.scopus2-s2.0-10444248029en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1016/j.vph.2004.05.004
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5613
dc.identifier.volume41en_US
dc.identifier.wosWOS:000226268800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜstündağ, Nil
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofVascular Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-tocopherolen_US
dc.subjectIschemia-reperfusion Injuryen_US
dc.subjectAprotininen_US
dc.subjectThiobarbituric Acid Reactive Substancesen_US
dc.titleAprotinin ameliorates ischemia/reperfusion injury in a rat hind limb modelen_US
dc.typeArticleen_US

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