The importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in familial Mediterraean fever

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dc.authorid0000-0002-7112-5658
dc.contributor.authorAkçan, Yusuf
dc.contributor.authorBayraktar, Yusuf
dc.contributor.authorArslan, Serap
dc.contributor.authorVan Thiel, David H.
dc.contributor.authorZerrin, B. C.
dc.contributor.authorYıldız, Oğuzhan
dc.date.accessioned2021-06-23T18:54:44Z
dc.date.available2021-06-23T18:54:44Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractFamilial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent fever of unknown origin, renal amyloidosis, peritonitis, pleuritis and/or synovitis. There have been many studies to elucidate the etiopathogenesis of FMF. IL-6 is a cytokine that can induce the formation of serum amyloid A and C-reactive protein, both of which are important in development of amyloidosis. IL-6 was determined to be strongly associated in the etiopathogenesis of periodic fever in Chinese-pei dogs. The dogs with this syndrome experience periodic fever, arthritis, renal amyloidosis, a clinical picture very alike of human FMF. Here, we aimed to study mainly whether IL-6 had a similar etiopathogenetic role in human FMF as in Chinese-pei dogs syndrome. The median IL-6 blood levels were found to be higher in patients with acute (n=8) FMF attack (1.85 U/ml) compared to those (n=33) with asymptomatic ones (1.0 U/ml) (p=0.16). There are mainly two results: first; the study should be designed with a larger sample size of patients with acute attack in order to alleviate underestimation of significance, second; sampling time may give various results because of dynamic changes of cytokine levels during acute attack period.en_US
dc.identifier.endpage306en_US
dc.identifier.issn0949-2321
dc.identifier.issue7en_US
dc.identifier.pmid12911867en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4558
dc.identifier.volume8en_US
dc.identifier.wosWOS:000184806200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkçan, Yusuf
dc.institutionauthorBayraktar, Yusuf
dc.institutionauthorArslan, Serap
dc.institutionauthorVan Thiel, David H.
dc.institutionauthorZerrin, B. C.
dc.institutionauthorYıldız, Oğuzhan
dc.language.isoenen_US
dc.relation.ispartofEuropean journal of medical researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMediterraeanen_US
dc.subjectSerial Measurements
dc.titleThe importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in familial Mediterraean feveren_US
dc.typeArticleen_US

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