The relationship between nitrate-induced headache and -blood viscosity: An observational prospective study

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dc.authorid0000-0001-8923-8709en_US
dc.authorid0000-0002-4297-1820en_US
dc.authorid0000-0002-3183-5815en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0001-7766-9560en_US
dc.authorid0000-0001-7831-2715en_US
dc.authorid0000-0002-5025-2367en_US
dc.contributor.authorToprak, Kenan
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorMemioğlu, Tolga
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorBiçer, Asuman
dc.contributor.authorDemirbağ, Recep
dc.contributor.authorErdoğdu, Hamza
dc.date.accessioned2024-07-31T06:40:05Z
dc.date.available2024-07-31T06:40:05Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractNitrates are one of the most prescribed medications in the treatment of angina pectoris today. Headache is the most common side effect of nitrates, and there is limited prospective data on the determinants of this effect. Our aim in this study is to open a foresight window for clinicians in clinical practice by explaining the possible relationship between nitrate-induced headache and whole-blood viscosity (WBV). After coronary revascularization treatment, 869 patients with angina who were prescribed nitrate preparations were divided into groups according to the development of headache or not and categorized according to the 4-grade scale level. Those who had no headache during nitrate use were graded as grade 0, those who felt mild headache were grade 1, those who felt moderate headache were grade 2, and those who described severe headache were graded as grade 3. The groups were compared according to WBV values. A total of 869 participants were included in the study. Most patients (82.1%) experienced some level of headache. Headache severity correlated with both WBV at high shear rate (r = 0.657; P < 0.001) and WBV at low shear rate (r = 0.687; P < 0.001). In multivariate analysis, WBV was determined as an independent predictor of headache experience. WBV predicted nitrate-induced headache with 75% sensitivity and 75% specificity at high shear rate and 77% sensitivity and 77% specificity at low shear rate. WBV seems to be one of the major determinants for nitrate-induced headache. WBV may be a guide for initiating alternative antianginal drugs without prescribing nitrates to the patient to increase patient compliance.en_US
dc.identifier.citationToprak, K., Kaplangöray, M., Memioglu, T., İnanır, M., Biçer, A., Demirbağ, R., & Erdoğdu, H. (2023). The Relationship Between Nitrate-Induced Headache and-Blood Viscosity: An Observational Prospective Study. Journal of Cardiovascular Pharmacology, 82(2), 162-168.en_US
dc.identifier.doi10.1097/FJC.0000000000001443
dc.identifier.endpage168en_US
dc.identifier.issn0160-2446
dc.identifier.issn1533-4023
dc.identifier.issue2en_US
dc.identifier.pmid37314267en_US
dc.identifier.scopus2-s2.0-85167476545en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage162en_US
dc.identifier.urihttp://dx.doi.org/10.1097/FJC.0000000000001443
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12294
dc.identifier.volume82en_US
dc.identifier.wosWOS:001044455000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMemioğlu, Tolga
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitrate-Induced Headacheen_US
dc.subjectWhole-Blood Viscosityen_US
dc.subjectHigh Shear Rateen_US
dc.subjectLow Shear Rateen_US
dc.subjectHemorheologyen_US
dc.subjectToleranceen_US
dc.titleThe relationship between nitrate-induced headache and -blood viscosity: An observational prospective studyen_US
dc.typeArticleen_US

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