The relationship between tumor budding and survival in colorectal carcinomas

I have reviewed the article entitled ‘The Relation ship Between Tumor Budding and Survival in Colorectal Carcinomas’, by Peltek Ozer et al.1 for the Revista da Associação Médica Brasileira The authors inves tigated tumor budding (TB) by its new definition and reported that TB was an independent prognostic factor in colorectal carcinoma, which was also associated with perineural invasion, lymph node metastasis, lymphovascular invasion, and survival. The association with TB and perineural invasion has been reported in only a few studies; thus, Peltek Ozer et al.’s1 study made a significant contribution to the literature.