The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis

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dc.authorid0000-0001-8540-1935
dc.authorid0000-0002-4060-3354
dc.contributor.authorÇöl, Cavit
dc.contributor.authorDinler, Kahraman
dc.contributor.authorHasdemir, Ahmet Oğuz
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T18:52:07Z
dc.date.available2021-06-23T18:52:07Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractContext: Several experimental studies have been carried out to explain the physiopathological mechanisms and to introduce endocrinological, enzymatic, biochemical and histopathological changes in organisms during acute pancreatitis. Objective: To evaluate the effect of an intraperitoneal injection of melatonin on serum amylase levels. Design: Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats. The rats were then divided into two groups: control and melatonin groups. Intervention: The serum amylase level was measured on the 7th day after acute pancreatitis had developed. In the melatonin group, an intraperitoneal injection of melatonin (20 mg/kg/day) was performed starting from the 2nd day after pancreatic duct ligation. Main outcome measure: The levels of serum amylase were measured with an auto analyzer. Results: It was found that the mean (±SD) level of serum amylase in the control group was 947±182 IU/mL while it was 358±177 IU/mL in the experimental group (P<0.001). Conclusions: The 20 mg/kg/day intraperitoneal injection of melatonin which was carried out for one week attenuated the serum amylase levels to a statistically significant degree. The researchers believe that intraperitoneal injections of melatonin decrease the severity of acute pancreatitis.en_US
dc.identifier.endpage309en_US
dc.identifier.issn1590-8577
dc.identifier.issue3en_US
dc.identifier.pmid19454824en_US
dc.identifier.scopus2-s2.0-68149162183en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4136
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-68149162183&partnerID=40&md5=b74fdcc250706331d50447f754267be2
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇöl, Cavit
dc.institutionauthorDinler, Kahraman
dc.institutionauthorHasdemir, Ahmet Oğuz
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.relation.ispartofJournal of the Pancreasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmylasesen_US
dc.subjectAnimal Experimentationen_US
dc.subjectMelatoninen_US
dc.subjectPancreatitis, Acute Necrotizingen_US
dc.titleThe effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitisen_US
dc.typeArticleen_US

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