Depression and anxiety disorders in COVID-19 survivors: Role of inflammatory predictors

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dc.authorid0000-0002-5708-3631en_US
dc.authorid0000-0002-7114-9334en_US
dc.authorid0000-0002-1376-1488en_US
dc.authorid0000-0002-7725-707Xen_US
dc.authorid0000-0002-6768-7973en_US
dc.authorid0000-0003-4221-2506en_US
dc.contributor.authorDemiryürek, Esra
dc.contributor.authorÇekiç, Deniz
dc.contributor.authorİşsever, Kubilay
dc.contributor.authorGenç, Ahmet Cihad
dc.contributor.authorYaylacı, Selçuk
dc.contributor.authorDemiryürek, Bekir Enes
dc.date.accessioned2023-07-27T06:53:45Z
dc.date.available2023-07-27T06:53:45Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Infection-triggered perturbation of the immune system, which was observed after previous coronavirus outbreaks, could induce psychiatric sequelae. The spreading of the Coronavirus-19 (COVID-19) pandemic could be associated with psychiatric implications. In this study, we aimed to evaluate the association between inflammatory biomarkers and the levels of depression and anxiety in patients who recovered from COVID-19. Methods: We screened 109 COVID-19 survivor adults for psychiatric symptoms on the 15th day of follow-up after discharge from the hospital. The patients were split into two groups, the ones with depression and anxiety, and the ones without depression or anxiety, after the psychiatric interview. Self-rating Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to assess the levels in patients with depression and anxiety. We collected and recorded the sociodemographic information, clinical data, and baseline inflammatory markers. Results: Higher baseline neutrophil/lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) were found in patients with depression and anxiety. Higher levels of depression and anxiety were found in younger and female patients. Besides, a significant correlation was found between BAI and ferritin levels in patients with anxiety, while no association was found between BAI and other inflammatory biomarkers. Moreover, no significant relationship was found between BDI scores and inflammatory biomarkers in patients with depression. Conclusion: COVID-19 primarily affects the respiratory and cardiovascular systems. Nonetheless, psychiatric involvement is not uncommon and can lead to severe problems if not detected and managed at an early stage. It is recommended that clinicians should be vigilant in terms of psychiatric involvement in COVID-19 patients presenting with high inflammatory parameters.en_US
dc.identifier.citationDemiryürek, E., Cekic, D., Işsever, K., Genc, A. C., Yaylaci, S., & Demiryürek, B. E. (2022). Depression and anxiety disorders in COVID-19 survivors: role of inflammatory predictors. Archives of Neuropsychiatry, 59(2), 105.en_US
dc.identifier.doi10.29399/npa.27698
dc.identifier.endpage109en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2en_US
dc.identifier.pmid35685053en_US
dc.identifier.scopus2-s2.0-85131265710en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage105en_US
dc.identifier.trdizinid518678en_US
dc.identifier.urihttp://dx.doi.org/10.29399/npa.27698
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11375
dc.identifier.volume59en_US
dc.identifier.wosWOS:000799769200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neuropsychiatry Association-Türk Nöropsikiyatri Derneğien_US
dc.relation.ispartofNoropsikiyatri Arşivi-Archives of Neuropsychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnxietyen_US
dc.subjectCOVID-19en_US
dc.subjectDepressionen_US
dc.subjectInflammationen_US
dc.subjectImmune-Systemen_US
dc.subjectInfectionen_US
dc.titleDepression and anxiety disorders in COVID-19 survivors: Role of inflammatory predictorsen_US
dc.typeArticleen_US

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