Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF

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dc.authorid0000-0003-4478-7514en_US
dc.authorid0000-0002-0717-1756en_US
dc.authorid0000-0003-3446-3751en_US
dc.authorid0000-0001-8354-780X
dc.authorid0000-0002-5110-5414
dc.contributor.authorÖnalan, Göğşen
dc.contributor.authorSelam, Belgin
dc.contributor.authorBaran, Yusuf
dc.contributor.authorCıncık, Mehmet
dc.contributor.authorÖnalan, Reşide
dc.contributor.authorGündüz, Ufuk
dc.contributor.authorUral, Ali Uğur
dc.date.accessioned2021-06-23T19:18:14Z
dc.date.available2021-06-23T19:18:14Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: There are limited data about the levels of soluble apoptotic factors and their modulation with therapeutic regimens in IVF cycles. The aim of the current study was to determine follicular fluid, and serum levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in PCOS patients undergoing IVF/ICSI cycles; also to investigate the effects of metformin on these factors and on apoptosis of luteinized granulosa cells. METHODS: We investigated the serum and follicular fluid levels of sFas and sFasL in patients with PCOS (n=28) and compared them with those of the patients with infertility due to male factor (n=12) undergoing IVF cycles. Effects of metformin therapy on these parameters and apoptosis of luteinized granulosa cells were also investigated among the patients with PCOS. RESULTS: Serum levels of sFas were significantly lower in the PCOS group compared to those in women with infertility due to male factor. Metformin therapy in PCOS patients preceding IVF cycles increased serum levels of sFas and decreased follicular fluid levels of sFasL compared to those on placebo. Follicular fluid from PCOS patients demonstrated luteinized granulosa cell DNA fragmentation in agarose gel, whereas a similar pattern was not observed among PCOS patients undergoing metformin therapy. CONCLUSION: Decreased serum levels of sFas and luteinized granulosa cell DNA fragmentation is observed in patients with PCOS undergoing IVF cycles. Metformin therapy preceding IVF demonstrates an antiapoptotic effect with increased serum levels of sFas, decreased follicular fluid levels of sFasL and prevention of luteinized granulosa cell DNA fragmentation.en_US
dc.identifier.doi10.1093/humrep/dei068
dc.identifier.endpage2395en_US
dc.identifier.issn0268-1161
dc.identifier.issue9en_US
dc.identifier.pmid15932917en_US
dc.identifier.scopus2-s2.0-24044552671en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2391en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/dei068
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5676
dc.identifier.volume20en_US
dc.identifier.wosWOS:000231362800004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSelam, Belgin
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectIVFen_US
dc.subjectMetforminen_US
dc.subjectPCOSen_US
dc.subjectSFasen_US
dc.titleSerum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVFen_US
dc.typeArticleen_US

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