Dipeptidyl peptidase IV (DDP IV) in NASH patients

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dc.authorid0000-0002-0901-9192en_US
dc.authorid0000-0002-7553-3915en_US
dc.authorid0000-0001-5663-0683en_US
dc.authorid0000-0001-8268-9662
dc.contributor.authorBalaban, Hatice Yasemin
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorŞimşek, Halis
dc.contributor.authorGökcan, Hale
dc.contributor.authorGedikoğlu, Gökhan
dc.date.accessioned2021-06-23T19:19:48Z
dc.date.available2021-06-23T19:19:48Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective(s): Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with unknown etiology. The insulin resistance, immune mechanisms and oxidative stress are the main factors in its pathogenesis. Dipeptidyl peptidase IV (DPPIV) or CD26 is a protein with endocrine and immune functions. This study aimed to elicudate the changes related to DPPIV in NASH patients. Methods: Serum and urinary DPPIV activities were measured in 31 NASH patients and 17 healthy controls. The liver biopsies of 29 patients were immunolabeled for CD26. Results: The mean age of patients were 46 +/- 11 years and 14 (45%) of them were female. The serum DPPIV activity was higher in patients (57.3 +/- 7.8 U/L) than controls (43.6 +/- 10.6 U/L) (p < 0.0001), and correlated with the histopathological grade (p = 0.038, r = 0.373) and hepatosteatosis (p = 0.018, r = 0.423) but not with stage (p = 0.286), class (p = 0.286) or CD26 staining (p = 0.743). The urinary DPPIV activity was similar in patients (1.52 +/- 0.94 U/mmol creatinine) and controls (1.37 +/- 0.68 U/mmol creatinine) (p = 0.861). Three acinar zones of liver had equal CD26 expression (p = 0.076). The intensity of CD26 immunostaining was correlated with histopathological grade (p = 0.001) and hepatosteatosis (p = 0.003) but no correlation with stage or class could be detected (p = 0.610 and 0.956, respectively). In Conclusions: The serum DPPIV activity and the staining intensity of CD26 in liver are correlated with histopathologic grade of NASH and hepatosteatosis. DPPIV can be proposed as a novel candidate with several potential functions in NASH pathogenesis.en_US
dc.identifier.doi10.1016/S1665-2681(19)31905-2
dc.identifier.endpage250en_US
dc.identifier.issn1665-2681
dc.identifier.issue4en_US
dc.identifier.pmid18007554en_US
dc.identifier.scopus2-s2.0-37549001305en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org/10.1016/S1665-2681(19)31905-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6007
dc.identifier.volume6en_US
dc.identifier.wosWOS:000254257100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBalaban, Hatice Yasemin
dc.language.isoenen_US
dc.publisherElsevier Espanaen_US
dc.relation.ispartofAnnals Of Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCD26en_US
dc.subjectDipeptidyl Peptidase IVen_US
dc.subjectNon-alcoholic Steatohepatitisen_US
dc.subjectMetabolic Syndromeen_US
dc.titleDipeptidyl peptidase IV (DDP IV) in NASH patientsen_US
dc.typeArticleen_US

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